Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.91 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | TLR2 | O60603 | 2/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599913 | 1.00 | KMT2A (0.91) | KMT2ALMNATSHRHTTHDAC3 | |
| SCHEMBL31652507 | 0.99 | KMT2A (0.89) | KMT2ALMNATSHRHTTHDAC3 | |
| SCHEMBL178890 | 0.95 | KMT2A (1.00) | KMT2AHTTEPHX2TLR2CASP3 | |
| SCHEMBL178760 | 0.95 | KMT2A (1.00) | KMT2AHTTEPHX2TLR2CASP3 | |
| SCHEMBL25143 | 0.95 | KMT2A (1.00) | KMT2AHTTEPHX2TLR2CASP3 | |
| SCHEMBL178761 | 0.95 | KMT2A (1.00) | KMT2AHTTEPHX2TLR2CASP3 | |
| SCHEMBL2182769 | 0.95 | KMT2A (1.00) | KMT2AHTTEPHX2TLR2CASP3 | |
| SCHEMBL17746959 | 0.95 | KMT2A (1.00) | KMT2AHTTEPHX2TLR2CASP3 | |
| SCHEMBL178759 | 0.95 | KMT2A (1.00) | KMT2AHTTEPHX2TLR2CASP3 | |
| SCHEMBL178758 | 0.95 | KMT2A (1.00) | KMT2AHTTEPHX2TLR2CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0383803-B1 | OLIGONUCLEOTIDE-POLYAMIDE CONJUGATES | HOWARD FLOREY INST OF (AU) | 2000-05-03 | — | — | EP | disclosed |
| EP-0972779-A2 | Oligonucleotide-polyamide conjugates | HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE (AU) | 2000-01-19 | — | — | EP | disclosed |
| US-5854410-A | Oligonucleoside cleavage compounds and therapies | GENTA INCORPORATED (US) | 1998-12-29 | — | — | US | disclosed |
| US-5846728-A | Oligonucleotide-polyamide conjugates | HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE (AU) | 1998-12-08 | — | — | US | disclosed |
| EP-0542887-B1 | PSORALEN CONJUGATED METHYLPHOSPHONATE OLIGONUCLEOTIDES AS THERAPEUTIC AGENTS FOR CHRONIC MYELOGENOUS LEUKEMIA | GENTA INC (US) | 1998-12-02 | — | — | EP | disclosed |
| US-5677440-A | Oligonucleotide-polyamide conjugates | HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE (AU) | 1997-10-14 | — | — | US | disclosed |
| US-5525465-A | Oligonucleotide-polyamide conjugates and methods of production and applications of the same | HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE (AU) | 1996-06-11 | — | — | US | disclosed |
| EP-0542887-A1 | PSORALEN CONJUGATED METHYLPHOSPHONATE OLIGONUCLEOTIDES AS THERAPEUTIC AGENTS FOR CHRONIC MYELOGENOUS LEUKEMIA | GENTA INCORPORATED (US) | 1993-05-26 | — | — | EP | disclosed |
| WO-1992002641-A1 | PSORALEN CONJUGATED METHYLPHOSPHONATE OLIGONUCLEOTIDES AS THERAPEUTIC AGENTS FOR CHRONIC MYELOGENOUS LEUKEMIA | GENTA INCORPORATED (US) | 1992-02-20 | — | — | WO | disclosed |
| WO-1992002532-A1 | IMPROVED NON-NUCLEOTIDE-BASED LINKER REAGENTS FOR OLIGOMERS | GENTA INCORPORATED (US) | 1992-02-20 | — | — | WO | disclosed |
| EP-0383803-A4 | OLIGONUCLEOTIDE-POLYAMIDE CONJUGATES | — | 1991-03-20 | — | — | EP | disclosed |
| EP-0383803-A1 | OLIGONUCLEOTIDE-POLYAMIDE CONJUGATES | HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE (AU) | 1990-08-29 | — | — | EP | disclosed |
| WO-1989003849-A1 | OLIGONUCLEOTIDE-POLYAMIDE CONJUGATES | HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY (AU) | 1989-05-05 | — | — | WO | disclosed |