Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CFD | P00746 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1317441 | 0.84 | KDM4E (0.69) | KDM4ELMNAALDH1A1KMT2AHPGD | |
| Hydrochloric Acid SCHEMBL11587962 | 0.82 | KDM4E (0.67) | KDM4ELMNAALDH1A1KMT2AHPGD | |
| SCHEMBL3379096 | 0.82 | KDM4E (0.49) | KDM4ELMNAALDH1A1KMT2AHPGD | |
| SCHEMBL14744132 | 0.82 | KDM4E (0.72) | KDM4ELMNAALDH1A1KMT2AHPGD | |
| SCHEMBL4274425 | 0.82 | KDM4E (0.49) | KDM4ELMNAALDH1A1KMT2AHPGD | |
| SCHEMBL11756782 | 0.81 | ACHE (0.52) | KDM4ELMNAALDH1A1KMT2AHPGD | |
| SCHEMBL10785208 | 0.81 | KMT2A (0.51) | ALDH1A1KMT2AHPGDCYP2C19RAB9A | |
| SCHEMBL3324155 | 0.81 | ACHE (0.62) | KDM4ELMNAALDH1A1ACHERAB9A | |
| SCHEMBL8320523 | 0.81 | MAPT (0.49) | KDM4ELMNAALDH1A1KMT2AHPGD | |
| SCHEMBL4274429 | 0.81 | KDM4E (0.51) | KDM4ELMNAALDH1A1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8748632-B2 | Positive allosteric modulators of group II mGluRs | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2014-06-10 | — | — | US | disclosed |
| US-20120071503-A1 | POSITIVE ALLOSTERIC MODULATORS OF GROUP II MGLURS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2012-03-22 | — | — | US | disclosed |
| US-4091097-A | A 2'-HYDROXY-3-CARBOXY-4,5-SUBSTITUTED-BENZANILIDE, ITS ESTERS AND SALTS | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JA) | 1978-05-23 | — | — | US | disclosed |
| US-4024253-A | BENZANILIDE DERIVATIVES | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JA) | 1977-05-17 | — | — | US | disclosed |
| US-3973038-A | N-SUBSTITUTED PHENYL 2-HYDROXY BENZAMIDES | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JA) | 1976-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071503-A1 | POSITIVE ALLOSTERIC MODULATORS OF GROUP II MGLURS | GRM2, GRM1, GRIN2C | KDM4E 1353/4885LMNA 4797/4885ALDH1A1 4343/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.