SCHEMBL8046993

SCHEMBL8046993

CCCCCCC1=NCC(C)[Si](C)(C)O1

nearest known ligand 0.38

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 1/20 0.34
EBP Q15125 1/20 0.31
SIGMAR1 Q99720 1/20 0.31
SPHK1 Q9NYA1 1/20 0.31
THRA P10827 1/20 0.31
THRB P10828 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15201428 0.73 EPHX2 (0.42) EPHX2EBPSIGMAR1SPHK1THRA
SCHEMBL15201541 0.73 EPHX2 (0.42) EPHX2EBPSIGMAR1SPHK1THRA
SCHEMBL15201426 0.73 EPHX2 (0.42) EPHX2EBPSIGMAR1SPHK1THRA
SCHEMBL10665201 0.66 EPHX2 (0.42) EPHX2SPHK1THRATHRB
SCHEMBL10491840 0.62 ALDH1A1 (0.35) EBPSIGMAR1THRATHRB
SCHEMBL10617486 0.62 ALDH1A1 (0.35) EBPSIGMAR1THRATHRB
SCHEMBL10616783 0.62 ALDH1A1 (0.35) EBPSIGMAR1THRATHRB
SCHEMBL15201350 0.62 ALDH1A1 (0.35) EBPSIGMAR1THRATHRB
SCHEMBL10619632 0.62 ALDH1A1 (0.35) EBPSIGMAR1THRATHRB
SCHEMBL15201476 0.62 ALDH1A1 (0.35) EBPSIGMAR1THRATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0661290-B1 Compounds containing 1-aza-3-oxa-4-silacyclohex-1-enyl groups, and tautomers of said compounds DOW CORNING ASIA LTD (JP) 2000-04-26 EP disclosed
US-5446180-A Compounds containing 1-aza-3-oxa-4-silacyclohex-1-enyl groups, and tautomers of said compounds DOW CORNING ASIA LTD. (JP) 1995-08-29 US disclosed
EP-0661290-A1 Compounds containing 1-aza-3-oxa-4-silacyclohex-1-enyl groups, and tautomers of said compounds DOW CORNING ASIA, Ltd. (JP) 1995-07-05 EP disclosed