Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | VNN1 | O95497 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14738426 | 0.83 | SPHK1 (0.43) | POLBSIRT1ALDH1A1SIGMAR1 | |
| SCHEMBL1034082 | 0.83 | SPHK1 (0.43) | POLBSIRT1ALDH1A1SIGMAR1 | |
| SCHEMBL5015327 | 0.80 | KDM4E (0.48) | KDM4EPOLBSIRT2SIRT1CHRNB2 | |
| SCHEMBL15007429 | 0.75 | SPHK1 (0.46) | SIRT1 | |
| SCHEMBL7419587 | 0.73 | SIRT2 (0.51) | SIRT2SIRT1 | |
| SCHEMBL6411650 | 0.73 | SIRT2 (0.51) | KDM4EPOLBSIRT2SIRT1RECQL | |
| SCHEMBL4379439 | 0.73 | KMT2A (0.61) | KDM4ECHRNB2CHRNA4ALDH1A1VNN1 | |
| SCHEMBL3173400 | 0.73 | SPHK1 (0.45) | HTT | |
| SCHEMBL3743415 | 0.71 | GRM2 (0.45) | KDM4EPOLBALDH1A1MAPTSIGMAR1 | |
| SCHEMBL10041824 | 0.70 | CHRNB2 (0.62) | KDM4ECHRNB2CHRNA4ALDH1A1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6121280-A | Azabicyclic rotomase inhibitors | PFIZER INC. (US) | 2000-09-19 | — | — | US | disclosed |