Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.48 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.45 |
| ▸ | NOS2 | P35228 | 5/20 | 0.43 |
| ▸ | NOS1 | P29475 | 4/20 | 0.43 |
| ▸ | NOS3 | P29474 | 3/20 | 0.43 |
| ▸ | GSR | P00390 | 2/20 | 0.41 |
| ▸ | ARG2 | P78540 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | GGT1 | P19440 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | GRM8 | O00222 | 1/20 | 0.39 |
| ▸ | GRM6 | O15303 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL8047291 | 1.00 | OTC (0.48) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL8040301 | 0.98 | OTC (0.47) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL8040299 | 0.98 | OTC (0.47) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL248897 | 0.98 | OTC (0.49) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL27692295 | 0.98 | OTC (0.49) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL150229 | 0.98 | OTC (0.49) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL150228 | 0.98 | OTC (0.49) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL27530824 | 0.98 | OTC (0.49) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL27190202 | 0.97 | OTC (0.48) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL9537954 | 0.94 | OTC (0.46) | OTCDDAH1NOS2NOS1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6013250-A | FOR FINISHING EFFECT AND SUPERIOR PROTECTION AGAINST ENVIRONMENTAL, CHEMICAL, AND GROOMING-ASSOCIATED DAMAGE | L'OREAL S. A. (FR) | 2000-01-11 | — | — | US | disclosed |