Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.49 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.46 |
| ▸ | NOS2 | P35228 | 6/20 | 0.44 |
| ▸ | NOS3 | P29474 | 5/20 | 0.44 |
| ▸ | NOS1 | P29475 | 5/20 | 0.44 |
| ▸ | GSR | P00390 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | GRM8 | O00222 | 1/20 | 0.40 |
| ▸ | GRM6 | O15303 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL150228 | 1.00 | OTC (0.49) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL248897 | 1.00 | OTC (0.49) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL27692295 | 1.00 | OTC (0.49) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL27530824 | 1.00 | OTC (0.49) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL27190202 | 0.98 | OTC (0.48) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL8047291 | 0.98 | OTC (0.48) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL8047296 | 0.98 | OTC (0.48) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL8040299 | 0.97 | OTC (0.47) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL8040301 | 0.97 | OTC (0.47) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL4203993 | 0.95 | OTC (0.46) | OTCDDAH1NOS2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2042 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260115155-A1 | STABLE FORMS OF CAPSAICIN PALMITATE FOR THE TREATMENT OF PAIN | CHORDA PHARMA INC (US) | 2026-04-30 | — | — | US | claimed |
| EP-4640204-A2 | HAIR COSMETIC COMPOSITION | Kao Corporation (JP) | 2025-10-29 | — | — | EP | claimed |
| EP-3831362-B1 | HAIR COSMETIC COMPOSITION | KAO CORP (JP) | 2025-10-15 | — | — | EP | claimed |
| WO-2025124086-A1 | MICROCARRIER, PREPARATION METHOD THEREFOR AND USE THEREOF, AND METHOD FOR CELL ADHERENT CULTURE AND RECOVERY | 国科温州研究院(温州生物材料与工程研究所) | 2025-06-19 | — | — | WO | claimed |
| CN-114728064-B | Antibody-containing formulations | 中外制药株式会社 | 2025-05-06 | — | — | CN | claimed |
| EP-4539880-A1 | HIGHLY CONCENTRATED ANTIBODY COMPOSITIONS | Sanofi (FR) | 2025-04-23 | — | — | EP | claimed |
| WO-2025076736-A1 | SQUEEZABLE FIBER-BASED BOTTLE WITH A PERSONAL CARE COMPOSITION | THE PROCTER & GAMBLE COMPANY (US) | 2025-04-17 | — | — | WO | claimed |
| WO-2025077840-A1 | SQUEEZABLE FIBER-BASED BOTTLE WITH A PERSONAL CARE COMPOSITION | THE PROCTER & GAMBLE COMPANY (US) | 2025-04-17 | — | — | WO | claimed |
| WO-2025077844-A1 | A BIODEGRADABLE FLEXIBLE PACKAGE WITH A PERSONAL CARE COMPOSITION | THE PROCTER & GAMBLE COMPANY (US) | 2025-04-17 | — | — | WO | claimed |
| WO-2025076732-A1 | A BIODEGRADABLE FLEXIBLE PACKAGE WITH A PERSONAL CARE COMPOSITION | THE PROCTER & GAMBLE COMPANY (US) | 2025-04-17 | — | — | WO | claimed |
| WO-1994016740-A1 | THE USE OF NITRIC OXIDE-DELIVERING COMPOUNDS FOR THE TREATMENT OR PREVENTION OF ALCOHOLIC LIVER INJURY | BRIGHAM AND WOMEN'S HOSPITAL (US) | 1994-08-04 | — | — | WO | claimed |
| US-5227007-A | PROCESS FOR PRODUCING CRYSTALS OF SALT OF ACIDIC AMINO ACID AND BASIC AMINO ACID | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-07-13 | — | — | US | claimed |
| EP-0342139-B1 | USE OF ARGININE ASPARTATE FOR THE MANUFACTURE OF A MEDICAMENT FOR TREATING CERTAIN INFLICTIONS OF THE MEMORY | CORTIAL S.A. (FR) | 1993-03-31 | — | — | EP | claimed |
| EP-0502007-A4 | METHOD FOR REDUCING BLOOD CHOLESTEROL USING ARGININE | — | 1992-11-19 | — | — | EP | claimed |
| EP-0502007-A1 | ARGININE NICOTINATE FOR REDUCING BLOOD CHOLESTEROL | BARBUL, Adrian (US) | 1992-09-09 | — | — | EP | claimed |
| EP-0477991-A1 | Process for producing crystals of salt of acidic amino acid and basic amino acid | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-04-01 | — | — | EP | claimed |
| WO-1991007188-A1 | METHOD FOR REDUCING BLOOD CHOLESTEROL USING ARGININE | BARBUL ADRIAN (US) | 1991-05-30 | — | — | WO | claimed |
| US-5019558-A | Cognition activators | MEDA PHARMA (FR) | 1991-05-28 | — | — | US | claimed |
| US-4804674-A | ENHANCING SPERM MOTILITY | EUROCELTIQUE, S.A. (LU) | 1989-02-14 | — | — | US | claimed |
| EP-0242980-A2 | Vaginal pharmaceutical composition | Euroceltique S.A. (LU) | 1987-10-28 | — | — | EP | claimed |