Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8051920 | 0.92 | TSHR (0.51) | HSD17B10ALDH1A1HPGDUSP2MAPK1 | |
| SCHEMBL8050857 | 0.90 | HSD17B10 (0.48) | HSD17B10ALDH1A1HPGDUSP2MAPK1 | |
| SCHEMBL8045522 | 0.89 | PKM (0.44) | HSD17B10ALDH1A1HPGDMAPK1TSHR | |
| SCHEMBL8051273 | 0.89 | TSHR (0.42) | HSD17B10ALDH1A1HPGDUSP2MAPK1 | |
| SCHEMBL8042290 | 0.89 | CA1 (0.42) | HSD17B10ALDH1A1HPGDUSP2MAPK1 | |
| SCHEMBL8043947 | 0.88 | TSHR (0.44) | HSD17B10ALDH1A1HPGDUSP2MAPK1 | |
| SCHEMBL8032457 | 0.88 | TSHR (0.41) | HSD17B10ALDH1A1HPGDUSP2MAPK1 | |
| SCHEMBL8051866 | 0.88 | NPSR1 (0.46) | HSD17B10ALDH1A1HPGDUSP2MAPK1 | |
| SCHEMBL8044199 | 0.88 | TSHR (0.41) | HSD17B10ALDH1A1HPGDUSP2MAPK1 | |
| SCHEMBL8042984 | 0.86 | TSHR (0.50) | HSD17B10ALDH1A1HPGDUSP2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |