Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 7/20 | 0.47 |
| ▸ | TOP2B | Q02880 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5001596 | 0.89 | TOP2A (0.45) | TOP2ATOP2BALDH1A1KDM4EHPGD | |
| SCHEMBL4998739 | 0.87 | TOP2A (0.52) | TOP2ATOP2BALDH1A1KDM4EHPGD | |
| SCHEMBL4996474 | 0.86 | TOP2A (0.46) | TOP2ATOP2BALDH1A1KDM4EHPGD | |
| SCHEMBL4998901 | 0.86 | TOP2A (0.46) | TOP2ATOP2BALDH1A1KDM4EHPGD | |
| SCHEMBL4987044 | 0.85 | KCNH2 (0.52) | TOP2ATOP2BALDH1A1KDM4EHPGD | |
| SCHEMBL5001743 | 0.83 | TOP2A (0.45) | TOP2ATOP2BALDH1A1KDM4EHPGD | |
| SCHEMBL5001842 | 0.81 | TOP2A (0.46) | TOP2ATOP2BALDH1A1KDM4EHPGD | |
| SCHEMBL8785240 | 0.80 | TOP2A (0.54) | TOP2ATOP2BALDH1A1KDM4EHPGD | |
| SCHEMBL4996735 | 0.79 | TOP2A (0.52) | TOP2ATOP2BALDH1A1KDM4EHPGD | |
| SCHEMBL7006246 | 0.79 | TOP2A (0.58) | TOP2ATOP2BALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6025370-A | METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS | TOYAMA CHEMICAL CO., LTD. (JP) | 2000-02-15 | — | — | US | disclosed |
| EP-0882725-A1 | QUINOLONECARBOXYLIC ACID DERIVATIVES OR SALTS THEREOF | TOYAMA CHEMICAL CO., LTD. (JP) | 1998-12-09 | — | — | EP | disclosed |