Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 7/20 | 0.54 |
| ▸ | TOP2B | Q02880 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8785244 | 0.85 | TOP2A (0.39) | TOP2ATOP2BALDH1A1POLBCHRM2 | |
| SCHEMBL8084266 | 0.85 | TOP2A (0.64) | TOP2ATOP2BALDH1A1POLBCHRM2 | |
| SCHEMBL8061657 | 0.84 | TOP2A (0.61) | TOP2ATOP2BALDH1A1POLBCHRM2 | |
| SCHEMBL4248696 | 0.84 | TOP2A (0.39) | TOP2ATOP2BALDH1A1POLBCHRM2 | |
| SCHEMBL143295 | 0.84 | TOP2A (0.60) | TOP2ATOP2BALDH1A1POLBCHRM2 | |
| SCHEMBL8927420 | 0.83 | ADRB2 (0.51) | TOP2ATOP2BALDH1A1KDM4ELMNA | |
| SCHEMBL4248698 | 0.82 | TOP2A (0.38) | TOP2ATOP2BALDH1A1POLBCHRM2 | |
| SCHEMBL2081014 | 0.82 | TOP2A (0.56) | TOP2ATOP2BALDH1A1POLBCHRM2 | |
| SCHEMBL4482132 | 0.82 | ALDH1A1 (0.58) | TOP2ATOP2BALDH1A1POLBCHRM2 | |
| SCHEMBL4996474 | 0.81 | TOP2A (0.46) | TOP2ATOP2BALDH1A1POLBCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1097423-A | Quinolone-and naphthyridonecarboxylic acid derivatives | BAYER AG (DE) | 1995-01-18 | — | — | CN | claimed |
| EP-0607825-A1 | 6-H-4-OXO-3-quinoline-carboxylic acids and their analogues as antibacterial agents | BAYER AG (DE) | 1994-07-27 | — | — | EP | claimed |
| US-5648567-A | INTERMEDIATES FOR BACTERICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1997-07-15 | — | — | US | disclosed |
| EP-0607826-B1 | Fluoro-trifluoromethylbenzoic acid derivatives | BAYER AG (DE) | 1997-05-07 | — | — | EP | disclosed |
| US-5493048-A | REACTING METALLIZED FLUORO-TRIFLUOROMETHYLBENZENE DERIVATIVE WITH CARBON DIOXIDE AND PRODUCT IS THEN HYDROLYSED WITH AN ACID TO FORM ACID, SIMILARLY HALOGENATION GIVE ACID HALIDE AND WITH ALCOHOL GIVES ESTER | BAYER AKTIENGESELLSCHAFT (DE) | 1996-02-20 | — | — | US | disclosed |
| US-5457104-A | Antibacterials | BAYER AKTIENGESELLSCHAFT (DE) | 1995-10-10 | — | — | US | disclosed |
| CN-1097423-A | Quinolone-and naphthyridonecarboxylic acid derivatives | BAYER AG (DE) | 1995-01-18 | — | — | CN | disclosed |
| EP-0607826-A1 | Fluoro-Trifluoromethylbenzoic acid derivatives | BAYER AG (DE) | 1994-07-27 | — | — | EP | disclosed |
| EP-0607825-A1 | 6-H-4-OXO-3-quinoline-carboxylic acids and their analogues as antibacterial agents | BAYER AG (DE) | 1994-07-27 | — | — | EP | disclosed |