Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | FDPS | P14324 | 1/20 | 0.35 |
| ▸ | PGK1 | P00558 | 1/20 | 0.33 |
| ▸ | PGK2 | P07205 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5897235 | 0.89 | LMNA (0.60) | LMNAFDPSPGK1PGK2CYP2C19 | |
| SCHEMBL8049770 | 0.87 | LMNA (0.43) | LMNAFDPS | |
| SCHEMBL9155595 | 0.79 | — | — | |
| SCHEMBL8049813 | 0.78 | LMNA (0.39) | LMNAFDPSPGK1PGK2CYP2C19 | |
| Ammonia Solution, Strong SCHEMBL11367502 | 0.77 | LMNA (0.36) | LMNAFDPSCYP2C19CA2L3MBTL1 | |
| SCHEMBL26067554 | 0.74 | — | — | |
| SCHEMBL14013084 | 0.74 | LMNA (0.36) | LMNA | |
| SCHEMBL8049787 | 0.74 | LMNA (0.42) | LMNAFDPSPGK1PGK2 | |
| SCHEMBL12663062 | 0.74 | LMNA (0.36) | LMNA | |
| SCHEMBL8052781 | 0.73 | LMNA (0.45) | LMNAFDPSCYP2C19L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0563096-B1 | NOVEL METHYLENEBISPHOSPHONIC ACID DERIVATIVES | LEIRAS OY (FI) | 2000-05-03 | — | — | EP | disclosed |
| US-5438048-A | Used for treatment of disorders related to metabolism of calcium and other bivalent metals; treats bone cancer, urolithiasis, rheumatoid arthritis, bone infection and bone degradation | LEIRAS OY (FI) | 1995-08-01 | — | — | US | disclosed |
| EP-0563096-A1 | NOVEL METHYLENEBISPHOSPHONIC ACID DERIVATIVES | LEIRAS OY (FI) | 1993-10-06 | — | — | EP | disclosed |
| WO-1992011267-A1 | NOVEL METHYLENEBISPHOSPHONIC ACID DERIVATIVES | LEIRAS OY (FI) | 1992-07-09 | — | — | WO | disclosed |