SCHEMBL8048626

SCHEMBL8048626

O=C(Nc1cccc(NC(=O)Oc2ccccc2)c1)Oc1ccccc1

nearest known ligand 0.81

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.76
KMT2A Q03164 3/20 0.68
ALDH1A1 P00352 7/20 0.64
MAPT P10636 4/20 0.64
KDM4E B2RXH2 2/20 0.64
GAA P10253 2/20 0.64
HTT P42858 1/20 0.64
SMN1; SMN2 Q16637 1/20 0.64
BCHE P06276 2/20 0.62
ACHE P22303 1/20 0.62
RAD51 Q06609 2/20 0.62
FAAH O00519 1/20 0.59
CYP3A4 P08684 1/20 0.59
MAPK1 P28482 1/20 0.59
POLB P06746 1/20 0.59
MEN1 O00255 2/20 0.58
THRB P10828 1/20 0.58
GFER P55789 1/20 0.58
TDP1 Q9NUW8 1/20 0.58
RAB9A P51151 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17355405 0.92 CYP1A2 (0.66) CYP1A2KMT2AALDH1A1MAPTKDM4E
SCHEMBL9479530 0.92 CYP1A2 (0.66) CYP1A2KMT2AALDH1A1MAPTKDM4E
SCHEMBL18842378 0.92 CYP1A2 (0.70) CYP1A2KMT2AALDH1A1MAPTKDM4E
Phenyl Phenylcarbamate SCHEMBL272994 0.90 ALDH1A1 (0.76) CYP1A2KMT2AALDH1A1MAPTKDM4E
SCHEMBL1569274 0.90 CYP1A2 (0.68) CYP1A2KMT2AALDH1A1MAPTKDM4E
SCHEMBL3989104 0.90 CYP1A2 (0.68) CYP1A2KMT2AALDH1A1MAPTKDM4E
SCHEMBL18848299 0.89 CYP1A2 (0.67) CYP1A2KMT2AALDH1A1MAPTKDM4E
SCHEMBL12655119 0.89 KMT2A (0.78) CYP1A2KMT2AALDH1A1MAPTKDM4E
SCHEMBL542089 0.88 CYP1A2 (0.80) CYP1A2KMT2AALDH1A1MAPTKDM4E
SCHEMBL8061299 0.88 CYP1A2 (0.66) CYP1A2KMT2AALDH1A1MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6143917-A FROM A DIARYL CARBONATE AND AN AMINE COMPOUND HAVING AT LEAST ONE HYDROGEN ATOM LOCATED AT AN N-POSITION UNDER MODERATE CONDITIONS AT A HIGH REACTION RATE WITH A HIGH SELECTIVITY AND WITH A HIGH YIELD UBE INDUSTRIES, LTD. (JP) 2000-11-07 US disclosed
EP-0902014-A1 PROCESS FOR PRODUCING ARYL CARBAMATES UBE INDUSTRIES LIMITED (JP) 1999-03-17 EP disclosed