Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 9/20 | 0.69 |
| ▸ | MAPK9 | P45984 | 9/20 | 0.69 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.69 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.52 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.52 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.52 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11430427 | 0.92 | MAPK8 (0.79) | MAPK8MAPK9MAPK10NPC1RAB9A | |
| SCHEMBL12039472 | 0.85 | MAPK8 (0.50) | MAPK8MAPK9MAPK10NPC1RAB9A | |
| SCHEMBL6746930 | 0.85 | MAPK8 (0.69) | MAPK8MAPK9MAPK10NPC1RAB9A | |
| SCHEMBL8037040 | 0.84 | MAPK8 (0.67) | MAPK8MAPK9MAPK10NPC1RAB9A | |
| SCHEMBL18121441 | 0.83 | MAPK8 (0.58) | MAPK8MAPK9MAPK10NPC1RAB9A | |
| SCHEMBL8044196 | 0.82 | MAPK8 (1.00) | MAPK8MAPK9MAPK10NPC1RAB9A | |
| SCHEMBL8033463 | 0.81 | MAPK8 (0.64) | MAPK8MAPK9MAPK10NPC1RAB9A | |
| SCHEMBL8046186 | 0.81 | MAPK8 (0.67) | MAPK8MAPK9MAPK10NPC1RAB9A | |
| SCHEMBL4786924 | 0.81 | MAPK8 (0.64) | MAPK8MAPK9MAPK10NPC1RAB9A | |
| Ethyl Chloride SCHEMBL8050699 | 0.80 | MAPK8 (0.61) | MAPK8MAPK9MAPK10NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160289224-A1 | Antifungal Treatment | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-10-06 | — | — | US | disclosed |
| US-6143765-A | ENZYME IHIBITORS OF PROTEIN | SUGEN, INC. (US) | 2000-11-07 | — | — | US | disclosed |
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| US-5883110-A | ORGANIC MOLECULES CAPABLE OF INHIBITING PROTEIN TYROSINE PHOSPHATASE ACTIVITY, AND THE USE OF SUCH MOLECULES TO TREAT VARIOUS DISEASE STATES INCLUDING DIABETES MELLITUS, GLIOMA, MELANOMA, KAPOSI'S SARCOMA, HEMANGIOMA, OVARIAN CANCER, BREAST | SUGEN, INC. (US) | 1999-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160289224-A1 | Antifungal Treatment | ERG28, CYP51A1, ATG13 | MAPK8 2506/4885MAPK9 1704/4885MAPK10 2751/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.