Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30686997 | 0.87 | JAK2 (0.30) | JAK2JAK1 | |
| SCHEMBL19560011 | 0.77 | — | — | |
| SCHEMBL30639341 | 0.73 | LATS1 (0.32) | — | |
| SCHEMBL30639342 | 0.73 | LATS1 (0.32) | — | |
| SCHEMBL29576569 | 0.73 | LATS1 (0.32) | JAK2JAK1 | |
| SCHEMBL14734142 | 0.73 | LATS1 (0.32) | — | |
| SCHEMBL30758491 | 0.72 | LATS1 (0.30) | — | |
| SCHEMBL15088381 | 0.71 | — | — | |
| SCHEMBL14754619 | 0.71 | LATS1 (0.31) | — | |
| SCHEMBL8063975 | 0.70 | MAPT (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2215093-B1 | NOVEL PIPERAZINO-DIHYDROTHIENOPYRIMIDINE DERIVATIVES | BOEHRINGER INGELHEIM INT (DE) | 2011-12-14 | — | — | EP | disclosed |
| WO-2009050236-A1 | NOVEL PIPERAZINO-DIHYDROTHIENOPYRIMIDINE DERIVATIVES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-23 | — | — | WO | disclosed |