Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.73 |
| ▸ | MAPT | P10636 | 2/20 | 0.73 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 3/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | APEX1 | P27695 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553437 | 1.00 | RAB9A (0.73) | RAB9ASMN1; SMN2MAPTHPGDNPSR1 | |
| SCHEMBL1578469 | 0.90 | RAB9A (0.83) | RAB9ASMN1; SMN2MAPTHPGDNPSR1 | |
| SCHEMBL25042562 | 0.88 | HPGD (0.58) | RAB9ASMN1; SMN2MAPTHPGDNPSR1 | |
| SCHEMBL30274227 | 0.88 | HPGD (0.58) | RAB9ASMN1; SMN2MAPTHPGDNPSR1 | |
| SCHEMBL25042262 | 0.88 | HPGD (0.58) | RAB9ASMN1; SMN2MAPTHPGDNPSR1 | |
| SCHEMBL31006333 | 0.88 | HPGD (0.58) | RAB9ASMN1; SMN2MAPTHPGDNPSR1 | |
| SCHEMBL8862856 | 0.88 | GAA (0.60) | RAB9ASMN1; SMN2MAPTHPGDNPSR1 | |
| SCHEMBL8862940 | 0.88 | GAA (0.60) | RAB9ASMN1; SMN2MAPTHPGDNPSR1 | |
| SCHEMBL7519591 | 0.88 | GAA (0.60) | RAB9ASMN1; SMN2MAPTHPGDNPSR1 | |
| SCHEMBL8862746 | 0.88 | GAA (0.60) | RAB9ASMN1; SMN2MAPTHPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009060158-A1 | 4- (4-CYANOPHENYL) -1- (3-TRIFLUOROMETHYLPHENYL) -3,4, 6, 7-TETRAHYDRO-1H-PYRROLO [3, 4- D] PYRIMIDINE-2, 5-DIONE DERIVATIVES AND THEIR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS | ARGENTA DISCOVERY LIMITED (GB) | 2009-05-14 | — | — | WO | disclosed |