SCHEMBL805047

C[C@@H](OC(=O)c1ccccc1)[C@H]1O[C@@H](n2ccc(=O)[nH]c2=O)[C@H](OC(=O)c2ccccc2)[C@@H]1OC(=O)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 8)

	gene	UniProt	supporting neighbours	confidence
▸	POLB	P06746	2/20	0.46

▸	MEN1	O00255	1/20	0.46

▸	USP2	O75604	1/20	0.46

▸	KMT2A	Q03164	1/20	0.46

▸	TDP1	Q9NUW8	2/20	0.45

▸	P2RY2	P41231	2/20	0.40

▸	P2RY12	Q9H244	1/20	0.39

▸	HSD17B10	Q99714	1/20	0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL23710652	1.00	POLB (0.46)	POLBMEN1USP2KMT2ATDP1
SCHEMBL13253090	0.88	TDP1 (0.47)	POLBMEN1USP2KMT2ATDP1
SCHEMBL800696	0.87	POLB (0.46)	POLBMEN1USP2KMT2ATDP1
SCHEMBL800240	0.87	POLB (0.46)	POLBMEN1USP2KMT2ATDP1
SCHEMBL8424399	0.84	RNASE1 (0.52)	POLBMEN1USP2KMT2A
SCHEMBL13253087	0.84	SLC28A1 (0.44)	P2RY2
SCHEMBL13253089	0.84	SLC28A1 (0.44)	P2RY2
SCHEMBL13253098	0.83	POLB (0.39)	POLBTDP1HSD17B10
SCHEMBL13253100	0.83	SLC28A1 (0.41)	P2RY2
SCHEMBL881945	0.83	POLB (0.44)	POLBMEN1USP2KMT2ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2012142523-A2	1'-SUBSTITUTED PYRIMIDINE N-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT	GILEAD SCIENCES, INC. (US)	2012-10-18	—	—	WO	disclosed
WO-2012040126-A1	SUBSTITUTED NUCLEOTIDE ANALOGS	ALIOS BIOPHARMA, INC. (US)	2012-03-29	—	—	WO	disclosed