Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Aceturic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.50 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.50 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.50 |
| ▸ | CTH | P32929 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.43 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | ECE1 | P42892 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aceturic Acid SCHEMBL497508 | 1.00 | GLRA1 (0.50) | GLRA1SLC6A9OR51E2CTHEGLN1 | |
| Aceturic Acid SCHEMBL29455652 | 0.90 | PAOX (0.46) | GLRA1SLC6A9OR51E2CTHEGLN1 | |
| Aceturic Acid SCHEMBL5876 | 0.89 | — | — | |
| Aceturic Acid SCHEMBL42918 | 0.89 | CTH (0.52) | CTHEGLN1MAPTALDH1A1LMNA | |
| Aceturic Acid SCHEMBL31348252 | 0.87 | — | — | |
| Aceturic Acid SCHEMBL2120015 | 0.87 | — | — | |
| Aceturic Acid SCHEMBL9438413 | 0.87 | — | — | |
| Aceturic Acid SCHEMBL31614105 | 0.87 | — | — | |
| Aceturic Acid SCHEMBL10710298 | 0.87 | CTH (0.50) | CTHEGLN1MAPTALDH1A1LMNA | |
| Aceturic Acid SCHEMBL9130077 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003854-A1 | Antimicrobial peptides derived from ubiquicidine | Rijksuniversiteit te Leiden (NL) | 2000-05-31 | — | — | EP | claimed |
| WO-1998054314-A1 | ANTIMICROBIAL PEPTIDES DERIVED FROM UBIQUICIDINE | RIJKSUNIVERSITEIT LEIDEN (NL) | 1998-12-03 | — | — | WO | claimed |