Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.86 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.86 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alcohol SCHEMBL1359754 | 1.00 | TSHR (0.86) | TSHRALDH1A1NFKB1KCNA1SMN1; SMN2 | |
| Alcohol SCHEMBL2849383 | 1.00 | — | — | |
| Alcohol SCHEMBL21062125 | 1.00 | — | — | |
| Alcohol SCHEMBL709842 | 1.00 | — | — | |
| Alcohol SCHEMBL11442066 | 0.94 | — | — | |
| Alcohol SCHEMBL9207184 | 0.94 | — | — | |
| Alcohol SCHEMBL8568674 | 0.94 | — | — | |
| Alcohol SCHEMBL18825542 | 0.94 | — | — | |
| Alcohol SCHEMBL7260944 | 0.94 | — | — | |
| Alcohol SCHEMBL12803525 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0791624-B1 | Silica reinforced rubber composition and tire with tread thereof | GOODYEAR TIRE & RUBBER (US) | 2000-05-31 | — | — | EP | disclosed |
| EP-0791624-A1 | Silica reinforced rubber composition and tire with tread thereof | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1997-08-27 | — | — | EP | disclosed |
| US-5610216-A | POLY(2-HYDROXYTRIMETHYLENE)SULFIDE, BIS/TRIALKOXYSILYLALKYL/POLYSULFIDE, COUPLERS | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1997-03-11 | — | — | US | disclosed |