Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 2/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | LDHB | P07195 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | GRK6 | P43250 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8057106 | 0.88 | RPS6KB1 (0.47) | RPS6KB1CSF1RLDHALDHBEGFR | |
| SCHEMBL8053837 | 0.84 | RPS6KB1 (0.47) | RPS6KB1CSF1RLDHALDHBEGFR | |
| SCHEMBL8049902 | 0.76 | RPS6KB1 (0.50) | RPS6KB1CSF1RLDHALDHBEGFR | |
| SCHEMBL15354441 | 0.65 | MAP4K4 (0.46) | EGFRLMNAHTTPKMHSD17B10 | |
| SCHEMBL15889091 | 0.64 | MAP4K4 (0.39) | EGFRLMNAHTTPKMHSD17B10 | |
| SCHEMBL666702 | 0.62 | RPS6KB1 (1.00) | RPS6KB1AURKB | |
| SCHEMBL10256310 | 0.62 | RPS6KB1 (1.00) | RPS6KB1AURKB | |
| SCHEMBL13064911 | 0.62 | HTT (0.38) | EGFRLMNAHTTPKMHSD17B10 | |
| SCHEMBL240657 | 0.61 | TP53 (0.41) | RPS6KB1EGFRHIF1ALMNAHTT | |
| SCHEMBL239850 | 0.61 | TP53 (0.41) | RPS6KB1EGFRHIF1ALMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999045016-A9 | NOVEL PRODRUGS FOR PHOSPHORUS-CONTAINING COMPOUNDS | METABASIS THERAPEUTICS INC (US) | 2000-03-02 | — | — | WO | disclosed |