Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
| ▸ | LDHA | P00338 | 1/20 | 0.38 |
| ▸ | LDHB | P07195 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | GRK6 | P43250 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8051613 | 0.88 | RPS6KB1 (0.45) | RPS6KB1LDHALDHBCSF1REGFR | |
| SCHEMBL8053837 | 0.81 | RPS6KB1 (0.47) | RPS6KB1LDHALDHBCSF1REGFR | |
| SCHEMBL8049902 | 0.78 | RPS6KB1 (0.50) | RPS6KB1LDHALDHBCSF1REGFR | |
| SCHEMBL4956721 | 0.69 | PDE8B (0.32) | JAK3 | |
| SCHEMBL15354441 | 0.65 | MAP4K4 (0.46) | EGFRJAK2LMNAHTTPKM | |
| SCHEMBL666702 | 0.64 | RPS6KB1 (1.00) | RPS6KB1 | |
| SCHEMBL10256310 | 0.64 | RPS6KB1 (1.00) | RPS6KB1 | |
| SCHEMBL15889091 | 0.64 | MAP4K4 (0.39) | EGFRADORA3LMNAHTTPKM | |
| SCHEMBL13064911 | 0.62 | HTT (0.38) | EGFRLMNAHTTPKMHSD17B10 | |
| SCHEMBL239850 | 0.61 | TP53 (0.41) | RPS6KB1EGFRHIF1ALMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999045016-A9 | NOVEL PRODRUGS FOR PHOSPHORUS-CONTAINING COMPOUNDS | METABASIS THERAPEUTICS INC (US) | 2000-03-02 | — | — | WO | disclosed |