Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 7/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043831 | 0.82 | DDB1 (0.36) | DDB1CRBNSCN9ANAMPT | |
| SCHEMBL12192502 | 0.82 | DDB1 (0.34) | DDB1CRBNSCN9ANAMPT | |
| SCHEMBL12217201 | 0.81 | DDB1 (0.34) | DDB1CRBNSCN9ANAMPT | |
| SCHEMBL8050931 | 0.80 | — | — | |
| SCHEMBL12192472 | 0.79 | DDB1 (0.34) | DDB1CRBNSCN9ANAMPT | |
| SCHEMBL12192457 | 0.79 | DDB1 (0.34) | DDB1CRBNSCN9ANAMPT | |
| SCHEMBL12192449 | 0.79 | GAA (0.36) | SCN9ARIPK1GAA | |
| SCHEMBL12549469 | 0.70 | DPP8 (0.38) | DDB1CRBNGAA | |
| SCHEMBL12549189 | 0.70 | DPP8 (0.37) | DDB1CRBNNAMPTGAADRD2 | |
| SCHEMBL6913773 | 0.69 | DDB1 (0.42) | DDB1CRBNNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8030307-B2 | Bicyclic, C5-substituted proline derivatives as inhibitors of the hepatitis C virus NS3 protease | ENANTA PHARMACEUTICALS, INC. (US) | 2011-10-04 | — | — | US | disclosed |
| US-8030307-B2 | Bicyclic, C5-substituted proline derivatives as inhibitors of the hepatitis C virus NS3 protease | ENANTA PHARMACEUTICALS, INC. (US) | 2011-10-04 | — | — | US | disclosed |
| WO-2009070689-A1 | BICYCLIC, C5-SUBSTITUTED PROLINE DERIVATIVES AS INHIBITORS OF THE HEPATITIS C VIRUS NS3 PROTEASE | ENANTA PHARMACEUTICALS, INC. (US) | 2009-06-04 | — | — | WO | disclosed |