⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3944498 | 0.58 | CES1 (0.35) | — | |
| SCHEMBL10514604 | 0.58 | — | — | |
| SCHEMBL2286878 | 0.56 | — | — | |
| SCHEMBL4394267 | 0.56 | — | — | |
| Iodide SCHEMBL11637460 | 0.54 | — | — | |
| SCHEMBL959790 | 0.53 | — | — | |
| SCHEMBL9484547 | 0.51 | — | — | |
| SCHEMBL9453880 | 0.51 | — | — | |
| SCHEMBL22485690 | 0.42 | CES2 (0.45) | — | |
| SCHEMBL452580 | 0.32 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998277-A1 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | Merck & Co., Inc. (a New Jersey corp.) (US) | 2000-05-10 | — | — | EP | claimed |
| WO-1998053809-A1 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO., INC. (US) | 1998-12-03 | — | — | WO | claimed |
| EP-0479480-A2 | Substituted thieno(2,3-B)(1,4)thiazine-6-sulfonamides as antiglaucoma agents | MERCK & CO. INC. (US) | 1992-04-08 | — | — | EP | disclosed |
| US-5093332-A | SUBSTITUTED THIENO(2,3-B)(1,4)THIAZINE-6-SULFONAMIDES AS ANTIGLAUCOMA AGENTS | MERCK & CO., INC. (US) | 1992-03-03 | — | — | US | disclosed |