Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 4/20 | 1.00 |
| ▸ | CPA3 | P15088 | 1/20 | 0.55 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.51 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1517804 | 0.89 | FOLH1 (0.81) | FOLH1GRM3NAALAD2 | |
| SCHEMBL28349776 | 0.89 | FOLH1 (0.81) | FOLH1GRM3NAALAD2 | |
| SCHEMBL6381682 | 0.87 | FOLH1 (0.78) | FOLH1CPA3GRM3NAALAD2 | |
| SCHEMBL8040925 | 0.86 | FOLH1 (0.76) | FOLH1CPA3GRM3NAALAD2 | |
| SCHEMBL8053977 | 0.84 | FOLH1 (0.73) | FOLH1CPA3GRM3NAALAD2 | |
| SCHEMBL26424193 | 0.84 | FOLH1 (0.72) | FOLH1CPA3GRM3NAALAD2 | |
| SCHEMBL7619756 | 0.84 | FOLH1 (0.72) | FOLH1CPA3GRM3NAALAD2 | |
| SCHEMBL7860305 | 0.81 | FOLH1 (0.67) | FOLH1CPA3 | |
| SCHEMBL4275480 | 0.80 | FOLH1 (0.67) | FOLH1 | |
| SCHEMBL8056003 | 0.80 | FOLH1 (0.67) | FOLH1CPA3GRM3NAALAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6054444-A | INHIBIT N-ACETYLATED ALPHA-LINKED ACIDIC DIPEPTIDASE (NAALADASE) ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-25 | — | — | US | claimed |
| US-9737552-B2 | Treatment of cognitive impairment in a subject with a neurological autoimmune disease | THE JOHNS HOPKINS UNIVERSITY (US) | 2017-08-22 | — | — | US | disclosed |
| US-9737552-B2 | Treatment of cognitive impairment in a subject with a neurological autoimmune disease | THE JOHNS HOPKINS UNIVERSITY (US) | 2017-08-22 | — | — | US | disclosed |
| WO-2012082903-A2 | TREATMENT OF COGNITIVE IMPAIRMENT IN A SUBJECT WITH A NEUROLOGICAL AUTOIMMUNE DISEASE | THE JOHNS HOPKINS UNIVERSITY (US) | 2012-06-21 | — | — | WO | disclosed |