Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Leucinamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.61 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.46 |
| ▸ | ANPEP | P15144 | 7/20 | 0.44 |
| ▸ | RNPEP | Q9H4A4 | 4/20 | 0.44 |
| ▸ | DNPEP | Q9ULA0 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LAP3 | P28838 | 2/20 | 0.41 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.39 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.37 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.37 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucine Amide SCHEMBL9274582 | 1.00 | SLC7A5 (0.61) | SLC7A5SLC1A3SLC1A2ANPEPRNPEP | |
| Leucine Amide SCHEMBL8052964 | 1.00 | SLC7A5 (0.61) | SLC7A5SLC1A3SLC1A2ANPEPRNPEP | |
| Leucine Amide SCHEMBL241528 | 0.97 | — | — | |
| Leucinamide SCHEMBL241527 | 0.97 | — | — | |
| Leucinamide SCHEMBL1989213 | 0.97 | — | — | |
| Leucine Amide SCHEMBL8081226 | 0.95 | SLC7A5 (0.61) | SLC7A5SLC1A3SLC1A2ANPEPRNPEP | |
| Leucinamide SCHEMBL1425296 | 0.95 | SLC7A5 (0.61) | SLC7A5SLC1A3SLC1A2ANPEPRNPEP | |
| Leucine Amide SCHEMBL1425294 | 0.95 | SLC7A5 (0.61) | SLC7A5SLC1A3SLC1A2ANPEPRNPEP | |
| Leucinamide SCHEMBL8081225 | 0.95 | SLC7A5 (0.61) | SLC7A5SLC1A3SLC1A2ANPEPRNPEP | |
| Leucinamide SCHEMBL1881755 | 0.95 | SLC7A5 (0.61) | SLC7A5SLC1A3SLC1A2ANPEPRNPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046016-A | PEPTIDASE ACTIVITY; N-(5-BROMO-3-INDOLYL)-LEUCINE OR ALANINE. | BIO MERIEUX (FR) | 2000-04-04 | — | — | US | disclosed |
| EP-0473700-A1 | AN ENZYME-CATALYZED PROCESS FOR PREPARING N-ACYL AMINO ACIDS AND N-ACYL AMINO ACID AMIDES | NOVO NORDISK A/S (DK) | 1992-03-11 | — | — | EP | disclosed |
| WO-1990014429-A1 | AN ENZYME-CATALYZED PROCESS FOR PREPARING N-ACYL AMINO ACIDS AND N-ACYL AMINO ACID AMIDES | NOVO NORDISK A/S (DK) | 1990-11-29 | — | — | WO | disclosed |