Leucine Amide

Leucine Amide

SCHEMBL1425294

CC(C)C[C@H](N)C(N)=O.Cl

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Leucine Amide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA2D1 known ✓ P54289 2/20 0.37
CACNB3 known ✓ P54284 1/20 0.37
CACNA1C known ✓ Q13936 1/20 0.37
ADRA1A known ✓ P35348 1/20 0.37
HTR2B known ✓ P41595 1/20 0.37
CACNA2D2 known ✓ Q9NY47 1/20 0.37
DPP4 known ✓ P27487 1/20 0.36
SLC7A5 Q01650 1/20 0.61
SLC1A3 P43003 3/20 0.46
SLC1A2 P43004 3/20 0.46
ANPEP P15144 7/20 0.44
RNPEP Q9H4A4 4/20 0.44
DNPEP Q9ULA0 2/20 0.44
ALDH1A1 P00352 1/20 0.41
TSHR P16473 1/20 0.41
MAPK1 P28482 1/20 0.41
LAP3 P28838 2/20 0.41
ERAP1 Q9NZ08 1/20 0.41
ELANE P08246 1/20 0.40
SLC1A1 P43005 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Leucinamide SCHEMBL1881755 1.00 SLC7A5 (0.61) SLC7A5SLC1A3SLC1A2ANPEPRNPEP
Leucinamide SCHEMBL1425296 1.00 SLC7A5 (0.61) SLC7A5SLC1A3SLC1A2ANPEPRNPEP
Leucinamide SCHEMBL241527 0.97
Leucinamide SCHEMBL1989213 0.97
Leucine Amide SCHEMBL241528 0.97
Leucine Amide SCHEMBL8081226 0.95 SLC7A5 (0.61) SLC7A5SLC1A3SLC1A2ANPEPRNPEP
Leucinamide SCHEMBL8081225 0.95 SLC7A5 (0.61) SLC7A5SLC1A3SLC1A2ANPEPRNPEP
Leucine Amide SCHEMBL8052964 0.95 SLC7A5 (0.61) SLC7A5SLC1A3SLC1A2ANPEPRNPEP
Leucine Amide SCHEMBL9274582 0.95 SLC7A5 (0.61) SLC7A5SLC1A3SLC1A2ANPEPRNPEP
Leucinamide SCHEMBL8052962 0.95 SLC7A5 (0.61) SLC7A5SLC1A3SLC1A2ANPEPRNPEP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 176 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0397652-B1 WATER INSOLUBLE DERIVATIVES OF HYALURONIC ACID GENZYME CORP (US) 1996-06-05 EP claimed
EP-0397652-A4 WATER INSOLUBLE DERIVATIVES OF HYALURONIC ACID 1991-04-03 EP claimed
EP-0397652-A1 WATER INSOLUBLE DERIVATIVES OF HYALURONIC ACID. GENZYME CORP (US) 1990-11-22 EP claimed
US-4937270-A Water insoluble derivatives of hyaluronic acid GENZYME CORPORATION (US) 1990-06-26 US claimed
WO-1989002445-A1 WATER INSOLUBLE DERIVATIVES OF HYALURONIC ACID GENZYME CORPORATION (US) 1989-03-23 WO claimed
US-12559514-B2 Synthesis of fluorinated nucleotides MERCK SHARP & DOHME LLC (US) 2026-02-24 US disclosed
US-20260027071-A1 COMPOSITION FOR PROMOTING COLLAGEN PRODUCTION COMPRISING AMIDATED AMINO ACID KYUNGPOOK NAT UNIV IND ACADEMIC COOP FOUND (KR) 2026-01-29 US disclosed
US-20260014098-A1 FENCHOL AS A STIMULATOR OF FREE FATTY ACID RECEPTOR AND OTHER USES THEREOF UNIV SOUTH FLORIDA (US) 2026-01-15 US disclosed
US-12447135-B2 Fenchol as a stimulator of free fatty acid receptor and other uses thereof UNIVERSITY OF SOUTH FLORIDA (US) 2025-10-21 US disclosed
EP-4483868-A1 COMPOSITION FOR PROMOTING COLLAGEN PRODUCTION COMPRISING AMIDATED AMINO ACID Boo, Yong Chool (KR) 2025-01-01 EP disclosed
US-20240218009-A1 NOVEL FORMS OF CYCLIC DINUCLEOTIDE COMPOUNDS MERCK SHARP & DOHME LLC (US) 2024-07-04 US disclosed
US-20240182511-A1 NOVEL FORMS OF CYCLIC DINUCLEOTIDE COMPOUNDS MERCK SHARP & DOHME LLC (US) 2024-06-06 US disclosed
EP-0326799-A2 Enzymatic process for synthesizing peptides Degussa Aktiengesellschaft (DE) 1989-08-09 EP disclosed
WO-1989002445-A1 WATER INSOLUBLE DERIVATIVES OF HYALURONIC ACID GENZYME CORPORATION (US) 1989-03-23 WO disclosed
WO-1988006890-A1 SYNTHETIC INHIBITORS OF MAMMALIAN COLLAGENASE RESEARCH CORPORATION TECHNOLOGIES, INC. (US) 1988-09-22 WO disclosed
US-4452814-A ANTITUMOR AGENTS SUAMI T (JP) 1984-06-05 US disclosed
US-4443367-A SYNTHETIC MONSANTO COMPANY (US) 1984-04-17 US disclosed
US-4425428-A Novel peptide and peptolide substrates for mammalian collagenase MONSANTO COMPANY (US) 1984-01-10 US disclosed
US-4384993-A FRACTURING IN PRESENCE OF WATER SOLUBLE NITROGEN COMPOUND JURIDICAL FOUNDATION THE CHEMO SERO-THERAPEUTIC RESEARCH INSTITUTE (JP) 1983-05-24 US disclosed
EP-0035616-A1 Production of immunoglobulin having a high monomer content Juridical Foundation The Chemo-Sero-Therapeutic Research Institute (JP) 1981-09-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240218009-A1 NOVEL FORMS OF CYCLIC DINUCLEOTIDE COMPOUNDS STING1, IFNAR1, CGAS CACNA2D1 4288/4885CACNB3 4458/4885CACNA1C 4394/4885
US-20260027071-A1 COMPOSITION FOR PROMOTING COLLAGEN PRODUCTION COMPRISING AMIDATED AMINO ACID COL2A1, COL14A1, GLS CACNA2D1 970/4885CACNB3 3220/4885CACNA1C 3292/4885
US-20260014098-A1 FENCHOL AS A STIMULATOR OF FREE FATTY ACID RECEPTOR AND OTHER USES THEREOF FFAR2, FFAR1, FFAR3 CACNA2D1 2017/4885CACNB3 438/4885CACNA1C 599/4885
US-12447135-B2 Fenchol as a stimulator of free fatty acid receptor and other uses thereof FFAR2, FFAR1, FFAR3 CACNA2D1 3898/4885CACNB3 1011/4885CACNA1C 1439/4885
US-12559514-B2 Synthesis of fluorinated nucleotides NUDT1, NSUN2, PNP CACNA2D1 336/4885CACNB3 2210/4885CACNA1C 855/4885
US-20240182511-A1 NOVEL FORMS OF CYCLIC DINUCLEOTIDE COMPOUNDS STING1, IFNAR1, CGAS CACNA2D1 3656/4885CACNB3 4547/4885CACNA1C 4397/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.