Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | MMP1 | P03956 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25545442 | 0.90 | MAPT (0.62) | PDE4BHDAC8HDAC1MAPTNPC1 | |
| SCHEMBL3171960 | 0.86 | PDE4B (0.79) | PDE4BHDAC8HDAC1MAPTNPC1 | |
| SCHEMBL4082864 | 0.86 | PDE4B (0.86) | PDE4BHDAC8HDAC1MAPTNPC1 | |
| SCHEMBL12855893 | 0.84 | PDE4B (0.62) | PDE4BHDAC8HDAC1MAPTNPC1 | |
| SCHEMBL28591673 | 0.83 | NPC1 (0.51) | PDE4BHDAC8HDAC1NPC1MMP1 | |
| SCHEMBL23782435 | 0.83 | MMP1 (0.56) | PDE4BMAPTNPC1RAB9AMMP1 | |
| SCHEMBL16552644 | 0.82 | MMP1 (0.76) | PDE4BHDAC8HDAC1MAPTNPC1 | |
| SCHEMBL7685854 | 0.81 | NPC1 (0.68) | NPC1RAB9AALDH1A1L3MBTL1POLB | |
| SCHEMBL30552506 | 0.81 | PDE4B (0.72) | PDE4BHDAC8HDAC1MAPTNPC1 | |
| SCHEMBL4530719 | 0.81 | PDE4B (0.72) | PDE4BHDAC8HDAC1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636367-B1 | Use of phenylalkylamines for producing cholesterol lowering agents | HOFFMANN LA ROCHE (CH) | 2000-03-29 | — | — | EP | disclosed |
| US-5637771-A | Compound useful for lowering cholesterol | HOFFMANN-LA ROCHE INC. (US) | 1997-06-10 | — | — | US | disclosed |
| EP-0636367-A1 | Use of phenylalkylamines for producing cholesterol lowering agents | F. HOFFMANN-LA ROCHE AG (CH) | 1995-02-01 | — | — | EP | disclosed |