Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 5/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.57 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 6/20 | 0.47 |
| ▸ | LDLR | P01130 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3753651 | 0.87 | MAPK8 (0.75) | MAPK8MAPK10CAMK2DMAPK9JAK2 | |
| SCHEMBL16404665 | 0.78 | CAMK2D (0.59) | MAPK8MAPK10CAMK2DMAPK9JAK2 | |
| SCHEMBL3753705 | 0.77 | MAPK8 (0.64) | MAPK8MAPK10CAMK2DMAPK9JAK2 | |
| SCHEMBL3753582 | 0.73 | MAPK8 (0.68) | MAPK8MAPK10CAMK2DMAPK9JAK2 | |
| SCHEMBL3753107 | 0.73 | MAPK8 (0.61) | MAPK8MAPK10CAMK2DMAPK9JAK2 | |
| SCHEMBL3759434 | 0.73 | MAPK8 (1.00) | MAPK8MAPK10CAMK2DMAPK9JAK2 | |
| SCHEMBL3756427 | 0.72 | MAPK8 (0.60) | MAPK8MAPK10JAK2CCNA2CDK2 | |
| SCHEMBL3753544 | 0.71 | MAPK8 (0.80) | MAPK8MAPK10CAMK2DMAPK9JAK2 | |
| SCHEMBL3754113 | 0.71 | MAPK8 (0.66) | MAPK8MAPK10CAMK2DMAPK9JAK2 | |
| SCHEMBL3759173 | 0.70 | MAPK8 (0.74) | MAPK8MAPK10JAK2CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009032861-A1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-03-12 | — | — | WO | disclosed |