SCHEMBL8053338

SCHEMBL8053338

CC=CCCc1ccc(C(=O)O)c(-c2cc(F)c(C#N)c(F)c2)c1

nearest known ligand 0.38

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
RARB P10826 3/20 0.38
RARA P10276 2/20 0.38
RARG P13631 1/20 0.38
S1PR1 P21453 5/20 0.37
GPR52 Q9Y2T5 1/20 0.35
LTB4R2 Q9NPC1 1/20 0.33
S1PR3 Q99500 2/20 0.33
S1PR5 Q9H228 2/20 0.33
SLC22A12 Q96S37 1/20 0.31
PPARA Q07869 1/20 0.31
HCAR2 Q8TDS4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28734245 1.00 RARB (0.38) RARBRARARARGS1PR1GPR52
SCHEMBL8048282 0.87 S1PR1 (0.42) RARBRARARARGS1PR1SLC22A12
SCHEMBL28734246 0.84 GPR52 (0.41) RARBRARARARGGPR52
SCHEMBL6567164 0.79 RARB (0.46) RARBRARARARGGPR52PPARA
SCHEMBL6567162 0.79 RARB (0.46) RARBRARARARGGPR52PPARA
SCHEMBL6567224 0.78 MAOB (0.34) GPR52
SCHEMBL6567232 0.78 MAOB (0.34) GPR52
SCHEMBL8860646 0.78 KDM1A (0.36) RARBRARARARG
SCHEMBL28734244 0.74 GPR52 (0.43) RARBGPR52
SCHEMBL9192514 0.73 SLC22A12 (0.40) RARBRARARARGS1PR1SLC22A12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0805134-B1 NOVEL LIQUID-CRYSTAL COMPOUNDS BEARING DIENYL MOIETY AND LIQUID-CRYSTAL COMPOSITION CHISSO CORP (JP) 2000-08-30 EP disclosed
US-6086964-A Liquid crystalline compound having dienyl moiety and liquid crystal composition CHISSO CORPORATION (JP) 2000-07-11 US disclosed
EP-0700982-B1 A liquid crystal composition and a liquid crystal display element using the same CHISSO CORP (JP) 2000-04-26 EP disclosed
US-6001275-A LIQUID CRYSTALLINE COMPOUND WHICH HAS A LARGE RATIO OF ELASTIC CONSTANTS, HAS A LOW VISCOSITY, EXCELLENT MISCIBILITY WITH OTHER LIQUID CRYSTALLINE COMPOUND, CHEMICALLY STABLE; HAVING AN UNCONJUGATED ALKADIENYL GROUP AT A SIDE CHAIN. CHISSO CORPORATION (JP) 1999-12-14 US disclosed
US-5720899-A Liquid crystalline compound, liquid crystal composition and liquid crystal display element CHISSO CORPORATION (JP) 1998-02-24 US disclosed
EP-0805134-A1 NOVEL LIQUID-CRYSTAL COMPOUNDS BEARING DIENYL MOIETY AND LIQUID-CRYSTAL COMPOSITION CHISSO CORPORATION (JP) 1997-11-05 EP disclosed
US-5653911-A Liquid crystalline compound liquid crystal composition and liquid crystal display element CHISSO CORPORATION (JP) 1997-08-05 US disclosed
EP-0700982-A1 A liquid crystal composition and a liquid crystal display element using the same Chisso Corporation (JP) 1996-03-13 EP disclosed