Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 17/20 | 0.56 |
| ▸ | CTSG | P08311 | 1/20 | 0.47 |
| ▸ | XIAP | P98170 | 2/20 | 0.46 |
| ▸ | CMA1 | P23946 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8053356 | 1.00 | ELANE (0.56) | ELANECTSGXIAPCMA1 | |
| SCHEMBL8613939 | 0.86 | XIAP (0.57) | ELANEXIAPCMA1 | |
| SCHEMBL8920341 | 0.86 | XIAP (0.57) | ELANEXIAPCMA1 | |
| SCHEMBL7206990 | 0.85 | ELANE (0.48) | ELANECTSGXIAPCMA1 | |
| SCHEMBL7860727 | 0.85 | ELANE (0.55) | ELANECMA1 | |
| SCHEMBL30582861 | 0.84 | XIAP (0.55) | ELANECTSGXIAPCMA1 | |
| SCHEMBL30216494 | 0.84 | XIAP (0.53) | ELANEXIAPCMA1 | |
| SCHEMBL8567599 | 0.83 | XIAP (0.56) | ELANECTSGXIAPCMA1 | |
| SCHEMBL8574659 | 0.83 | XIAP (0.56) | ELANECTSGXIAPCMA1 | |
| SCHEMBL770146 | 0.83 | XIAP (0.46) | ELANEXIAPCMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130315-A | SUBSTRATES IN WHICH THE SCISSILE AMIDE BOND HAS BEEN REPLACED BY AN ACTIVATED ELECTROPHILIC KETONE MOIETY; ANTIINFLAMMATORY AGENTS; ANTIPROLIFERATIVE/ANTICARCINOGENIC/ANTIARTHRITIC AGENTS; TREATMENT OF AUTOIMMUNE DISEASES | MERRELL PHARMACEUTICALS INC. (US) | 2000-10-10 | — | — | US | disclosed |
| US-5849866-A | Peptidase inhibitors | MERRELL PHARMACEUTICALS INC. (US) | 1998-12-15 | — | — | US | disclosed |
| US-5496927-A | INHIBITORS OF HUMAN LEUKOCYTE ELASTASE, CATHEPSIN G, CHYMOTRYPSIN | MERRELL PHARMACEUTICALS INC. (US) | 1996-03-05 | — | — | US | disclosed |
| EP-0195212-B1 | Novel peptidase inhibitors | MERRELL DOW PHARMA (US) | 1993-11-24 | — | — | EP | disclosed |
| EP-0195212-A2 | Novel peptidase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-09-24 | — | — | EP | disclosed |