Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 9/20 | 0.43 |
| ▸ | UBA3 | Q8TBC4 | 9/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.33 |
| ▸ | UBA1 | P22314 | 1/20 | 0.32 |
| ▸ | UBE2E1 | P51965 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL782980 | 0.81 | NAE1 (0.68) | NAE1UBA3UBA1UBE2E1 | |
| SCHEMBL17145363 | 0.81 | NAE1 (0.68) | NAE1UBA3UBA1UBE2E1 | |
| SCHEMBL18540533 | 0.78 | NAE1 (0.56) | NAE1UBA3UBA1UBE2E1 | |
| SCHEMBL805391 | 0.77 | NAE1 (0.68) | NAE1UBA3MERTKCDC7GSK3B | |
| SCHEMBL805406 | 0.76 | NAE1 (0.45) | NAE1UBA3MAPK9MAPK8CYP1A2 | |
| SCHEMBL10283699 | 0.73 | NAE1 (0.55) | NAE1UBA3CA1CA2 | |
| SCHEMBL2879594 | 0.71 | NAE1 (0.49) | NAE1UBA3CA1CA2 | |
| SCHEMBL2879589 | 0.71 | NAE1 (0.49) | NAE1UBA3CA1CA2 | |
| SCHEMBL805408 | 0.70 | NAE1 (0.64) | NAE1UBA3CA1CA2 | |
| SCHEMBL10283692 | 0.70 | NAE1 (0.64) | NAE1UBA3CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071482-A1 | HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF E1 ACTIVATING ENZYMES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071482-A1 | HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF E1 ACTIVATING ENZYMES | RCE1, ECE1, UBE2E1 | NAE1 24/4885UBA3 6/4885CDK7 85/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.