Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 14/20 | 0.48 |
| ▸ | UBA3 | Q8TBC4 | 13/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | SAE1 | Q9UBE0 | 5/20 | 0.33 |
| ▸ | UBA2 | Q9UBT2 | 4/20 | 0.33 |
| ▸ | UBA6 | A0AVT1 | 1/20 | 0.33 |
| ▸ | ATG7 | O95352 | 1/20 | 0.33 |
| ▸ | UBA7 | P41226 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.32 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | GRK5 | P34947 | 1/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL782606 | 0.87 | NAE1 (0.61) | NAE1UBA3SAE1UBA2 | |
| SCHEMBL805369 | 0.82 | NAE1 (0.46) | NAE1UBA3CDK2SAE1UBA2 | |
| SCHEMBL10283691 | 0.82 | NAE1 (0.52) | NAE1UBA3SAE1UBA2UBA6 | |
| SCHEMBL805382 | 0.79 | NAE1 (0.43) | NAE1UBA3SAE1UBA2UBA6 | |
| SCHEMBL805383 | 0.76 | NAE1 (0.56) | NAE1UBA3CDK2 | |
| SCHEMBL805376 | 0.75 | NAE1 (0.53) | NAE1UBA3SAE1UBA2 | |
| SCHEMBL782553 | 0.74 | NAE1 (0.67) | NAE1UBA3SAE1UBA2 | |
| SCHEMBL782316 | 0.72 | NAE1 (0.80) | NAE1UBA3 | |
| SCHEMBL12453619 | 0.72 | NAE1 (0.53) | NAE1UBA3CDK2SAE1UBA2 | |
| SCHEMBL16155027 | 0.70 | NAE1 (0.64) | NAE1UBA3SAE1UBA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071482-A1 | HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF E1 ACTIVATING ENZYMES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071482-A1 | HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF E1 ACTIVATING ENZYMES | RCE1, ECE1, UBE2E1 | NAE1 24/4885UBA3 6/4885CDK2 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.