Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 3/20 | 0.44 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HPN | P05981 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.36 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.36 |
| ▸ | ALOX15B | O15296 | 1/20 | 0.36 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14305948 | 0.80 | SLC5A2 (0.50) | KMT2AMEN1NPC1SLC5A2MAPT | |
| SCHEMBL12841087 | 0.79 | SLC5A2 (0.39) | KMT2AMEN1HTR2CHTR2AHTR2B | |
| SCHEMBL30717247 | 0.78 | ACHE (0.48) | KMT2AMEN1ACHEHTR2CHTR2A | |
| SCHEMBL5852622 | 0.78 | ACHE (0.48) | KMT2AMEN1ACHEHTR2CHTR2A | |
| SCHEMBL12508616 | 0.78 | SLC6A2 (0.31) | SLC6A4SLC6A3 | |
| SCHEMBL10258351 | 0.78 | CYP3A4 (0.42) | KMT2AMEN1ALDH1A1MAPK1ALOX15 | |
| SCHEMBL12641997 | 0.78 | KDM1A (0.44) | KMT2AMEN1HTR2CHTR2AHTR2B | |
| SCHEMBL12812849 | 0.78 | — | — | |
| SCHEMBL723465 | 0.77 | ACHE (0.46) | KMT2AMEN1ACHEHTR2CHTR2A | |
| SCHEMBL13818128 | 0.75 | HTR2C (0.47) | KMT2AMEN1ACHEHTR2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009042092-A1 | 2-ARYL OR HETEROARYL INDOLE DERIVATIVES | MERCK & CO., INC. (US) | 2009-04-02 | — | — | WO | disclosed |