Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRB2 | P62993 | 1/20 | 0.47 |
| ▸ | CALCRL | Q16602 | 3/20 | 0.44 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | RAMP1 | O60894 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8054560 | 1.00 | GRB2 (0.47) | GRB2CALCRLCAPN1OPRM1OPRD1 | |
| SCHEMBL10336230 | 0.94 | GRB2 (0.45) | GRB2CAPN1OPRM1OPRD1OPRK1 | |
| SCHEMBL31064871 | 0.88 | CAPN1 (0.48) | GRB2CALCRLCAPN1SLC6A2 | |
| SCHEMBL29471808 | 0.84 | GRB2 (0.48) | GRB2CALCRLCAPN1 | |
| SCHEMBL30435105 | 0.84 | OPRM1 (0.46) | GRB2OPRM1OPRD1OPRK1 | |
| SCHEMBL30434514 | 0.83 | F2 (0.45) | GRB2OPRM1OPRD1OPRK1 | |
| SCHEMBL30443935 | 0.82 | CALCRL (0.46) | GRB2CALCRLOPRM1SLC6A2RAMP1 | |
| SCHEMBL31412203 | 0.82 | GRB2 (0.46) | GRB2CALCRLCAPN1 | |
| SCHEMBL29547288 | 0.81 | GRB2 (0.48) | GRB2CALCRLCAPN1 | |
| SCHEMBL29546551 | 0.81 | GRB2 (0.48) | GRB2CALCRLCAPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112749-A | Recombinant DNA sequences for attenuated bacterium, Salmonella or Shigella and epitopes | PRAXIS BIOLOGICS, INC. (US) | 1992-05-12 | — | — | US | claimed |
| EP-0383833-A4 | VACCINES FOR MALARIA | — | 1990-11-07 | — | — | EP | claimed |
| EP-0383833-A1 | VACCINES FOR MALARIA | AMERICAN CYANAMID COMPANY (US) | 1990-08-29 | — | — | EP | claimed |
| WO-1989002924-A1 | VACCINES FOR MALARIA | PRAXIS BIOLOGICS, INC. (US) | 1989-04-06 | — | — | WO | claimed |
| WO-2018175633-A1 | METHODS OF INDUCING ANTI-MALARIAL IMMUNE RESPONSES AND COMPOSITIONS RELATED THERETO | LA JOLLA PHARMACEUTICAL COMPANY (US) | 2018-09-27 | — | — | WO | disclosed |
| US-6130082-A | EXPRESSION VECTOR CODING FUSION PROTEIN CAPABLE OF ELICITING AN IMMUNE RESPONSE AGAINST INFECTION BY THE HETEROLOGOUS MICROORGANISM | AMERICAN CYANAMID COMPANY (US) | 2000-10-10 | — | — | US | disclosed |
| EP-0419513-B1 | RECOMBINANT FLAGELLIN VACCINES | PRAXIS BIOLOG INC (US) | 1995-04-26 | — | — | EP | disclosed |
| US-5112749-A | Recombinant DNA sequences for attenuated bacterium, Salmonella or Shigella and epitopes | PRAXIS BIOLOGICS, INC. (US) | 1992-05-12 | — | — | US | disclosed |
| EP-0419513-A1 | RECOMBINANT FLAGELLIN VACCINES. | PRAXIS BIOLOG INC (US) | 1991-04-03 | — | — | EP | disclosed |
| WO-1989010967-A1 | RECOMBINANT FLAGELLIN VACCINES | PRAXIS BIOLOGICS, INC. (US) | 1989-11-16 | — | — | WO | disclosed |