Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1A1 | Q02108 | 18/20 | 0.52 |
| ▸ | GUCY1B1 | Q02153 | 18/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3039821 | 0.93 | GUCY1A1 (0.55) | GUCY1A1GUCY1B1KEAP1NFE2L2 | |
| SCHEMBL3039313 | 0.90 | GUCY1A1 (0.64) | GUCY1A1GUCY1B1 | |
| SCHEMBL3036974 | 0.90 | GUCY1A1 (0.55) | GUCY1A1GUCY1B1 | |
| SCHEMBL3034925 | 0.89 | GUCY1A1 (0.58) | GUCY1A1GUCY1B1KEAP1NFE2L2 | |
| SCHEMBL3042115 | 0.89 | GUCY1A1 (0.56) | GUCY1A1GUCY1B1 | |
| SCHEMBL3039833 | 0.89 | GUCY1A1 (0.55) | GUCY1A1GUCY1B1KEAP1NFE2L2 | |
| SCHEMBL3041079 | 0.89 | GUCY1A1 (0.55) | GUCY1A1GUCY1B1 | |
| SCHEMBL3030448 | 0.88 | GUCY1A1 (0.58) | GUCY1A1GUCY1B1KEAP1NFE2L2 | |
| SCHEMBL3033894 | 0.87 | GUCY1A1 (0.57) | GUCY1A1GUCY1B1KEAP1NFE2L2 | |
| SCHEMBL8052156 | 0.86 | GUCY1A1 (0.55) | GUCY1A1GUCY1B1KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8507512-B2 | Soluble guanylate cyclase activators | MERCK SHARP & DOHME CORP. (US) | 2013-08-13 | — | — | US | disclosed |
| US-8507512-B2 | Soluble guanylate cyclase activators | MERCK SHARP & DOHME CORP. (US) | 2013-08-13 | — | — | US | disclosed |
| US-20100216764-A1 | Soluble Guanylate Cyclase Activators | MERCK SHARP & DOHME LLC | 2010-08-26 | — | — | US | disclosed |
| US-20100216764-A1 | Soluble Guanylate Cyclase Activators | MERCK SHARP & DOHME LLC | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216764-A1 | Soluble Guanylate Cyclase Activators | GUCY1B1, GUCY1A1, GUCY1A2 | GUCY1A1 2/4885GUCY1B1 1/4885KEAP1 2087/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.