SCHEMBL8055003

SCHEMBL8055003

C=CCCC1=CCC(c2ccc(C#N)cc2)CC1

nearest known ligand 0.37

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 1/20 0.32
DRD3 P35462 1/20 0.32
GRIA1 P42261 1/20 0.32
GRIA2 P42262 1/20 0.32
GRIA3 P42263 1/20 0.32
USP30 Q70CQ3 1/20 0.31
KCNH2 Q12809 1/20 0.31
HRH3 Q9Y5N1 1/20 0.31
CYP19A1 P11511 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8047922 0.96 HRH3 (0.36) DRD2DRD3GRIA1GRIA2GRIA3
SCHEMBL8037929 0.95 KCNJ1 (0.34) DRD2DRD3KCNH2CYP19A1
SCHEMBL8052182 0.87 TSHR (0.33) KCNH2
SCHEMBL8048836 0.87 GRIA1 (0.33) GRIA1GRIA2GRIA3
SCHEMBL8037453 0.86 TSHR (0.34) KCNH2
SCHEMBL8049022 0.84 HRH3 (0.33) GRIA1GRIA2GRIA3KCNH2HRH3
SCHEMBL8049910 0.82 SRD5A1 (0.35) DRD2
SCHEMBL8055258 0.82
SCHEMBL8047956 0.82 HRH3 (0.37) GRIA1GRIA2GRIA3KCNH2HRH3
SCHEMBL8047950 0.82 HRH3 (0.37) GRIA1GRIA2GRIA3KCNH2HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0728829-B1 Liquid crystalline alkenylcyclohexene derivative, liquid crystal composition and liquid crystal display element CHISSO CORP (JP) 2000-05-03 EP disclosed
US-5698136-A LOW TEMPERATURE COMPATIBILITY, CHEMICAL STABILITY CHISSO CORPORATION (JP) 1997-12-16 US disclosed
EP-0728829-A2 Liquid crystalline alkenylcyclohexene derivative, liquid crystal composition and liquid crystal display element CHISSO CORPORATION (JP) 1996-08-28 EP disclosed