Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.44 |
| ▸ | CA7 | P43166 | 3/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMO | Q99835 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24477693 | 0.92 | CA12 (0.38) | CA12CA7CA14CA9JAK2 | |
| SCHEMBL24773688 | 0.88 | CA12 (0.55) | CA12CA7CA14CA9JAK2 | |
| SCHEMBL13580619 | 0.87 | CA12 (0.36) | CA12CA7CA14CA9JAK2 | |
| SCHEMBL17778087 | 0.82 | CA12 (0.44) | CA12CA7CA14CA9JAK2 | |
| SCHEMBL15996338 | 0.82 | CA12 (0.44) | CA12CA7CA14CA9JAK2 | |
| Formic Acid SCHEMBL28800887 | 0.79 | JAK2 (0.32) | CA12CA7CA14JAK2JAK1 | |
| Formic Acid SCHEMBL27819071 | 0.79 | JAK2 (0.32) | CA12CA7CA14JAK2JAK1 | |
| SCHEMBL18855930 | 0.78 | CA12 (0.56) | CA12CA7CA14CA9ALDH1A1 | |
| SCHEMBL12970652 | 0.78 | CA12 (0.50) | CA12CA7CA14CA9JAK2 | |
| SCHEMBL10206536 | 0.77 | CA12 (0.44) | CA12CA7CA14CA9JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009016498-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC. (US) | 2009-02-05 | — | — | WO | disclosed |