Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.45 |
| ▸ | NOS1 | P29475 | 1/20 | 0.45 |
| ▸ | NOS2 | P35228 | 1/20 | 0.45 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.36 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.33 |
| ▸ | PDE1A | P54750 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.33 |
| ▸ | LATS1 | O95835 | 1/20 | 0.33 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19965938 | 0.76 | NOS3 (0.53) | NOS3NOS1NOS2LNPEPHTT | |
| SCHEMBL22020965 | 0.73 | NOS3 (0.48) | NOS3NOS1NOS2LNPEPHTT | |
| SCHEMBL2480680 | 0.73 | NOS3 (0.58) | NOS3NOS1NOS2LNPEPHTT | |
| SCHEMBL5053503 | 0.70 | NOS3 (0.46) | NOS3NOS1NOS2LNPEPSMN1; SMN2 | |
| SCHEMBL18237549 | 0.69 | NOS3 (0.53) | NOS3NOS1NOS2LNPEPHTT | |
| SCHEMBL16660696 | 0.69 | NOS3 (0.48) | NOS3NOS1NOS2LNPEPHTT | |
| SCHEMBL29999712 | 0.68 | HTT (0.50) | NOS3NOS1NOS2HTTSMN1; SMN2 | |
| SCHEMBL21879335 | 0.67 | KCNQ2 (0.43) | NOS3NOS1NOS2LNPEPHTT | |
| SCHEMBL8533330 | 0.66 | NOS3 (0.59) | NOS3NOS1NOS2LNPEPHTT | |
| SCHEMBL2624104 | 0.66 | NOS3 (0.59) | NOS3NOS1NOS2LNPEPHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071657-A1 | TRIAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071657-A1 | TRIAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | GSK3B, GSK3A, CDK19 | NOS3 836/4885NOS1 2443/4885NOS2 2918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.