SCHEMBL8055890

SCHEMBL8055890

Cc1ccc(Nc2ccc(CC=O)cc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.50
MEN1 O00255 5/20 0.42
KMT2A Q03164 5/20 0.42
GAA P10253 4/20 0.42
L3MBTL1 Q9Y468 2/20 0.42
G6PD P11413 1/20 0.42
NPC1 O15118 2/20 0.42
ALDH1A1 P00352 2/20 0.41
MAPT P10636 3/20 0.41
POLB P06746 2/20 0.41
RAPGEF4 Q8WZA2 1/20 0.41
APP P05067 1/20 0.41
KDM4E B2RXH2 1/20 0.40
HSP90AA1 P07900 1/20 0.40
HSP90AB1 P08238 1/20 0.40
THRB P10828 1/20 0.40
ALOX15 P16050 1/20 0.40
MAPK1 P28482 1/20 0.40
CASP1 P29466 1/20 0.40
BLM P54132 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29443 0.87 IDO1 (0.48) ALDH1A1MAPTLMNACA1CA2
SCHEMBL28101173 0.87 IDO1 (0.48) ALDH1A1MAPTLMNACA1CA2
SCHEMBL27275726 0.84 IDO1 (0.46) ALDH1A1MAPTLMNACA1CA2
Acetaldehyde SCHEMBL27507154 0.82 IDO1 (0.44) ALDH1A1MAPTLMNACA1CA2
SCHEMBL6608023 0.81 ALDH1A1 (0.56) HPGDMEN1KMT2AGAAL3MBTL1
SCHEMBL5473166 0.79 CNR1 (0.40) MEN1KMT2AALDH1A1MAPTHSD17B10
SCHEMBL9516537 0.76 HPGD (0.78) HPGDMEN1KMT2AGAAL3MBTL1
SCHEMBL108881 0.76 HPGD (0.78) HPGDMEN1KMT2AGAAL3MBTL1
SCHEMBL50079 0.76 HPGD (0.78) HPGDMEN1KMT2AGAAL3MBTL1
SCHEMBL3661513 0.76 ALDH1A1 (0.44) MEN1KMT2AGAAL3MBTL1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0998449-A1 METHOD FOR AMINATING MONONUCLEAR AROMATIC COMPOUNDS AND POLYNUCLEAR COMPOUNDS CONTAINING AT LEAST ONE AROMATIC RING IN THE PRESENCE OF AN PALLADIUM COMPLEX CATALYST Celanese Chemicals Europe GmbH (DE) 2000-05-10 EP disclosed
WO-1999001418-A1 METHOD FOR AMINATING MONONUCLEAR AROMATIC COMPOUNDS AND POLYNUCLEAR COMPOUNDS CONTAINING AT LEAST ONE AROMATIC RING IN THE PRESENCE OF AN PALLADIUM COMPLEX CATALYST CELANESE CHEMICALS EUROPE GMBH (DE) 1999-01-14 WO disclosed