Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 9/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL785914 | 0.89 | CYP1A2 (0.49) | HSD11B1CYP1A2CYP2D6CYP2C19CLK4 | |
| SCHEMBL14529268 | 0.89 | DPP4 (0.46) | HSD11B1CYP1A2CYP2D6CYP2C19CLK4 | |
| SCHEMBL14393908 | 0.85 | CYP1A2 (0.43) | HSD11B1CYP1A2CYP2D6CYP2C19CLK4 | |
| SCHEMBL14471570 | 0.82 | CYP1A2 (0.48) | HSD11B1CYP1A2CYP2D6CYP2C19CLK4 | |
| SCHEMBL805589 | 0.81 | HSD11B1 (0.51) | HSD11B1CYP1A2CYP2D6CYP2C19CLK4 | |
| SCHEMBL15495466 | 0.77 | PDK2 (0.53) | HSD11B1CYP1A2CYP2D6CYP2C19CLK4 | |
| SCHEMBL802782 | 0.76 | GSK3A (0.46) | CYP1A2CYP2D6CYP2C19CLK4CYP2C9 | |
| SCHEMBL14471568 | 0.75 | PARP1 (0.42) | HSD11B1CYP1A2CYP2D6CYP2C19CLK4 | |
| SCHEMBL786243 | 0.75 | KMT2A (0.60) | HSD11B1CYP1A2CYP2D6CYP2C19CLK4 | |
| SCHEMBL786785 | 0.75 | CYP1A2 (0.48) | CYP1A2CYP2D6CYP2C19CLK4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071657-A1 | TRIAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-03-22 | — | — | US | disclosed |
| US-7691853-B2 | Pyrazole compounds useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-04-06 | — | — | US | disclosed |
| US-7390815-B2 | Pyrazole compounds useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071657-A1 | TRIAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | GSK3B, GSK3A, CDK19 | HSD11B1 2833/4885CYP1A2 3042/4885CYP2D6 4165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.