Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Indole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.40 |
| ▸ | BTK | Q06187 | 5/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 4/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.34 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.34 |
| ▸ | ITGAL | P20701 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA6 | P23280 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2027216 | 0.81 | CDK2 (0.63) | CYP1A2CDK2CCNB2CDK1CCNB1 | |
| Adenine SCHEMBL9737077 | 0.76 | CDK2 (0.56) | CYP1A2CDK2CCNB2CDK1CCNB1 | |
| SCHEMBL10222465 | 0.75 | CYP1A2 (0.51) | CYP1A2CDK2CCNB2CDK1CCNB1 | |
| SCHEMBL17693471 | 0.71 | TSHR (0.52) | CYP1A2CDK2CCNB2CDK1CCNB1 | |
| SCHEMBL17693470 | 0.71 | TSHR (0.52) | CYP1A2CDK2CCNB2CDK1CCNB1 | |
| SCHEMBL15950878 | 0.71 | TSHR (0.66) | CYP1A2CDK2CCNB2CDK1CCNB1 | |
| SCHEMBL49689 | 0.71 | TSHR (0.66) | CYP1A2CDK2CCNB2CDK1CCNB1 | |
| SCHEMBL14876945 | 0.71 | TSHR (0.66) | CYP1A2CDK2CCNB2CDK1CCNB1 | |
| SCHEMBL8712368 | 0.70 | TSHR (0.46) | CYP1A2CDK2CCNB2CDK1CCNB1 | |
| Hydrochloric Acid SCHEMBL584648 | 0.70 | TSHR (0.64) | CYP1A2CDK2CCNB2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153811-A | Method for reduction of transgene copy number | DEKALB GENETICS CORPORATION (US) | 2000-11-28 | — | — | US | disclosed |
| US-6040497-A | FERTILE TRANSGENIC CORN PLANTS COMPRISING OF A CHROMOSOMAL CASSETTE ENCODING A MODIFIED 5-ENOLPYRUVYL-3-PHOSPHOSHILIKIMIC ACID SYNTHASE GENE; FOR CONTROLLING WEEDS WHILE MAINTAING RESISTANT TO THE HERBICIDE GLYPHOSATE | DEKALB GENETICS CORPORATION (US) | 2000-03-21 | — | — | US | disclosed |
| US-6025545-A | REPRODUCIBLE SYSTEM FOR THE PRODUCTION OF STABLE, GENETICALLY TRANSFORMED MAIZE CELLS, AND TO METHODS OF SELECTING CELLS THAT HAVE BEEN TRANSFORMED | DEKALB GENETICS CORPORATION (US) | 2000-02-15 | — | — | US | disclosed |
| US-5990390-A | FERTILE TRANSGENIC ZEA MAYS PLANT WITH HETEROLOGOUS CHIMERIC DNA WHICH CAN BE TRANSMITTED TO PROGENY GENERATION AND CONFERS INSECT RESISTANCE | DEKALB GENETICS CORPORATION (US) | 1999-11-23 | — | — | US | disclosed |
| US-5969213-A | CEREAL PLANTS, OTHER THAN MAIZE OR RICE, THAT COMPRISE AN EXOGENOUS DNA EXPRESSING PHOSPHINOTHRICIN ACETYL TRANSFERASE TO IMPART RESISTANCE TO PHOSPHINOTHRICIN IN SAID CEREAL PLANTS. | DEKALB GENETICS CORPORATION (US) | 1999-10-19 | — | — | US | disclosed |
| US-5874265-A | CONTACTING MONOCOTYLEDONOUS CELLS OTHER THAN MAIZE OR RICE WITH DNA COMPOSITION COMPRISING PHOSPHINOTHRICIN ACETYL TRANSFERASE GENE UNDER CONDITIONS OF MICROPROJECTILE BOMBARDING ALLOWING UPTAKE OF DNA; REGENERATING PLANTS | DEKALB GENETICS CORPORATION (US) | 1999-02-23 | — | — | US | disclosed |
| US-5780709-A | WATER AND SALT STRESS RESISTANCE | DEKALB GENETICS CORPORATION (US) | 1998-07-14 | — | — | US | disclosed |
| US-5550318-A | INTRODUCING STREPTOMYCES BAR GENE BY MICROPROJECTILE BOMBARDMENT FOLLOWED BY EXPOSURE TO HERBICIDE BIALAPHOS | DEKALB GENETICS CORPORATION (US) | 1996-08-27 | — | — | US | disclosed |
| US-5489520-A | GENETIC ENGINEERING OF MONOCOTYLEDONS, ESPECIALLY CORN, BY BOMBARDMENT OF SEED EMBRYOS BY DNA-COATED MICROPROJECTILES, THE DNA COMPRISING A MARKER GENE ENCODING FOR PHOSPHINOTHRICIN ACETYL TRANSFERASE | DEKALB GENETICS CORPORATION (US) | 1996-02-06 | — | — | US | disclosed |