SCHEMBL8056677

SCHEMBL8056677

NC1=NC(c2ccccc2Cl)Cc2ccccc21

nearest known ligand 0.68

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
NOS3 P29474 16/20 0.68
NOS2 P35228 10/20 0.68
TAAR1 Q96RJ0 1/20 0.49
TSHR P16473 1/20 0.39
DPP4 P27487 1/20 0.38
HTR2A P28223 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8063260 0.81 NOS3 (1.00) NOS3NOS2TSHR
SCHEMBL8063271 0.81 NOS3 (0.68) NOS3NOS2TAAR1TSHR
Hydrochloric Acid SCHEMBL8098028 0.80 NOS3 (0.67) NOS3NOS2TAAR1TSHRHTR2A
Hydrochloric Acid SCHEMBL8099166 0.80 NOS3 (0.97) NOS3NOS2TSHR
SCHEMBL8045541 0.78 NOS3 (1.00) NOS3NOS2
Hydrochloric Acid SCHEMBL8098271 0.77 NOS3 (0.97) NOS3NOS2
SCHEMBL251337 0.77 NOS3 (1.00) NOS3NOS2
Hydrochloric Acid SCHEMBL8097464 0.76 NOS3 (0.97) NOS3NOS2TSHR
SCHEMBL8063313 0.75 NOS3 (0.72) NOS3NOS2TAAR1
SCHEMBL8045481 0.75 NOS3 (0.59) NOS3NOS2TSHRHTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1027052-A1 NOVEL COMBINATION AstraZeneca UK Limited (GB) 2000-08-16 EP claimed
US-6046191-A PHARMACEUTICAL COMBINATION COMPRISING A COX-2 INHIBITOR OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND AN AMIDINE COMPOUND; FOR TREATMENT OF INFLAMMATORY DISORDERS ASTRA PHARMACEUTICALS LTD. (GB) 2000-04-04 US claimed
WO-1999018960-A1 NOVEL COMBINATION ASTRAZENECA UK LIMITED (GB) 1999-04-22 WO claimed
EP-0892784-A1 AMINOISOQUINOLINES AND AMINOTHIENOPYRIDINE DERIVATIVES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS Astra Pharmaceuticals Limited (GB) 1999-01-27 EP claimed
WO-1997038977-A1 AMINOISOQUINOLINES AND AMINOTHIENOPYRIDINE DERIVATIVES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS ASTRA PHARMACEUTICALS LTD. (GB) 1997-10-23 WO claimed
EP-1027052-A1 NOVEL COMBINATION AstraZeneca UK Limited (GB) 2000-08-16 EP disclosed
US-6063789-A Aminoisoquinolines and aminotheinopyridine derivatives and their use as anti-inflammatory agents ASTRA PHARMACEUTICALS, LTD. (GB) 2000-05-16 US disclosed
US-6046191-A PHARMACEUTICAL COMBINATION COMPRISING A COX-2 INHIBITOR OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND AN AMIDINE COMPOUND; FOR TREATMENT OF INFLAMMATORY DISORDERS ASTRA PHARMACEUTICALS LTD. (GB) 2000-04-04 US disclosed
WO-1999018960-A1 NOVEL COMBINATION ASTRAZENECA UK LIMITED (GB) 1999-04-22 WO disclosed