SCHEMBL8056685

SCHEMBL8056685

NC1=NC(c2ccncc2)Cc2ccccc21

nearest known ligand 0.79

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
NOS3 P29474 19/20 0.79
NOS2 P35228 13/20 0.70
CYP19A1 P11511 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8098147 0.98 NOS3 (0.77) NOS3NOS2CYP19A1
SCHEMBL251337 0.88 NOS3 (1.00) NOS3NOS2
Hydrochloric Acid SCHEMBL8097464 0.87 NOS3 (0.97) NOS3NOS2
SCHEMBL8056698 0.83 NOS3 (0.72) NOS3NOS2CYP19A1
SCHEMBL8045541 0.83 NOS3 (1.00) NOS3NOS2
SCHEMBL8057575 0.83 NOS3 (1.00) NOS3NOS2
SCHEMBL8057510 0.83 NOS3 (0.77) NOS3NOS2
SCHEMBL8060998 0.83 NOS3 (0.77) NOS3NOS2
Hydrochloric Acid SCHEMBL8090444 0.82 NOS3 (0.70) NOS3NOS2CYP19A1
SCHEMBL8063157 0.82 NOS3 (0.70) NOS3NOS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6046191-A PHARMACEUTICAL COMBINATION COMPRISING A COX-2 INHIBITOR OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND AN AMIDINE COMPOUND; FOR TREATMENT OF INFLAMMATORY DISORDERS ASTRA PHARMACEUTICALS LTD. (GB) 2000-04-04 US claimed
EP-0892784-A1 AMINOISOQUINOLINES AND AMINOTHIENOPYRIDINE DERIVATIVES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS Astra Pharmaceuticals Limited (GB) 1999-01-27 EP claimed
WO-1997038977-A1 AMINOISOQUINOLINES AND AMINOTHIENOPYRIDINE DERIVATIVES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS ASTRA PHARMACEUTICALS LTD. (GB) 1997-10-23 WO claimed
EP-1027052-A1 NOVEL COMBINATION AstraZeneca UK Limited (GB) 2000-08-16 EP disclosed
US-6046191-A PHARMACEUTICAL COMBINATION COMPRISING A COX-2 INHIBITOR OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND AN AMIDINE COMPOUND; FOR TREATMENT OF INFLAMMATORY DISORDERS ASTRA PHARMACEUTICALS LTD. (GB) 2000-04-04 US disclosed
WO-1999018960-A1 NOVEL COMBINATION ASTRAZENECA UK LIMITED (GB) 1999-04-22 WO disclosed