Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGDS | O60760 | 2/20 | 0.43 |
| ▸ | FAAH | O00519 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7915792 | 0.93 | SMN1; SMN2 (0.47) | SMN1; SMN2THRBGAAHPGDSFAAH | |
| SCHEMBL558040 | 0.87 | SMN1; SMN2 (0.55) | SMN1; SMN2THRBGAAHPGDSFAAH | |
| SCHEMBL3102619 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2THRBGAAHPGDSFAAH | |
| SCHEMBL3104584 | 0.76 | HTT (0.56) | SMN1; SMN2THRBGAAFAAHMAPT | |
| SCHEMBL209179 | 0.73 | NR4A2 (0.46) | SMN1; SMN2THRBGAAFAAHCKS1B | |
| SCHEMBL3088419 | 0.73 | HTT (0.52) | SMN1; SMN2FAAHMAPTGPR119MEN1 | |
| SCHEMBL440844 | 0.72 | SMN1; SMN2 (0.65) | SMN1; SMN2THRBGAAHPGDSMAPT | |
| SCHEMBL1653518 | 0.72 | TUBB4A (0.60) | SMN1; SMN2THRBGAAHPGDSFAAH | |
| SCHEMBL27811555 | 0.72 | NR4A2 (0.48) | THRBPOLBKDM4EHTR2B | |
| SCHEMBL16597919 | 0.72 | BTK (0.49) | SMN1; SMN2THRBGAAHPGDSFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009050248-A1 | SUBSTITUTED PIPERIDINO-DIHYDROTHIENOPYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-23 | — | — | WO | disclosed |