Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 3/20 | 0.61 |
| ▸ | HTR1B | P28222 | 2/20 | 0.61 |
| ▸ | DRD2 | P14416 | 9/20 | 0.57 |
| ▸ | DRD3 | P35462 | 8/20 | 0.57 |
| ▸ | DRD4 | P21917 | 3/20 | 0.57 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8061970 | 0.95 | DRD2 (0.64) | HTR1DHTR1BDRD2DRD3DRD4 | |
| SCHEMBL8394822 | 0.80 | HTR1D (0.61) | HTR1DHTR1BDRD2DRD3DRD4 | |
| SCHEMBL8394827 | 0.80 | HTR1D (0.61) | HTR1DHTR1BDRD2DRD3DRD4 | |
| SCHEMBL8394825 | 0.80 | HTR1D (0.61) | HTR1DHTR1BDRD2DRD3DRD4 | |
| SCHEMBL15190320 | 0.79 | HTR1D (0.62) | HTR1DHTR1BDRD2DRD3DRD4 | |
| Bromide SCHEMBL11262994 | 0.78 | DRD2 (0.69) | HTR1DHTR1BDRD2DRD3DRD4 | |
| SCHEMBL11575568 | 0.78 | SRD5A2 (0.46) | DRD2DRD3 | |
| SCHEMBL7403722 | 0.77 | PRMT5 (0.55) | HTR1DHTR1BDRD2DRD3DRD4 | |
| SCHEMBL7403721 | 0.77 | PRMT5 (0.55) | HTR1DHTR1BDRD2DRD3DRD4 | |
| SCHEMBL4106723 | 0.76 | HTR1D (0.70) | HTR1DHTR1BDRD2DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817767-B1 | BICYCLIC AMINE DERIVATIVES AND THEIR USE AS ANTI-PSYCHOTIC AGENTS | SMITHKLINE BEECHAM PLC (GB) | 2000-05-24 | — | — | EP | disclosed |
| US-6008219-A | Bicyclic amine derivatives and their use as anti-psychotic agents | SMITHKLINE BEECH P.L.C. (GB) | 1999-12-28 | — | — | US | disclosed |
| WO-1996030333-A1 | BICYCLIC AMINE DERIVATIVES AND THEIR USE AS ANTI-PSYCHOTIC AGENTS | SMITHKLINE BEECHAM PLC (GB) | 1996-10-03 | — | — | WO | disclosed |