Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 13/20 | 0.46 |
| ▸ | JAK3 | P52333 | 6/20 | 0.46 |
| ▸ | TYK2 | P29597 | 3/20 | 0.46 |
| ▸ | JAK1 | P23458 | 3/20 | 0.46 |
| ▸ | SMG1 | Q96Q15 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8052958 | 0.86 | JAK2 (0.39) | MAPK8MAPK10MAPK9JAK2JAK3 | |
| SCHEMBL13081436 | 0.83 | MAPK8 (0.52) | MAPK8MAPK10MAPK9JAK2JAK3 | |
| SCHEMBL13081496 | 0.77 | MAPK8 (0.50) | MAPK8MAPK10MAPK9JAK2JAK3 | |
| SCHEMBL13081434 | 0.77 | MAPK8 (0.58) | MAPK8MAPK10MAPK9JAK2JAK3 | |
| SCHEMBL8051682 | 0.77 | MAPK8 (0.56) | MAPK8MAPK10MAPK9JAK2JAK3 | |
| SCHEMBL13081581 | 0.76 | MAPK8 (0.57) | MAPK8MAPK10MAPK9JAK2JAK3 | |
| SCHEMBL13081016 | 0.76 | MAPK8 (0.57) | MAPK8MAPK10MAPK9JAK2JAK3 | |
| SCHEMBL8040865 | 0.75 | MAPK8 (0.54) | MAPK8MAPK10MAPK9JAK2JAK3 | |
| SCHEMBL3751033 | 0.75 | MAPK10 (0.88) | MAPK8MAPK10MAPK9JAK2JAK3 | |
| SCHEMBL13081580 | 0.75 | MAPK8 (0.56) | MAPK8MAPK10MAPK9JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009032861-A1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-03-12 | — | — | WO | disclosed |