Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 10/20 | 0.59 |
| ▸ | HTR1D | P28221 | 8/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.52 |
| ▸ | HTR1A | P08908 | 3/20 | 0.52 |
| ▸ | DRD1 | P21728 | 2/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.52 |
| ▸ | HTR6 | P50406 | 1/20 | 0.52 |
| ▸ | HTR1F | P30939 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8058248 | 1.00 | HTR1B (0.59) | HTR1BHTR1DSLC6A4HTR1ADRD1 | |
| SCHEMBL8058265 | 0.82 | HTR1B (0.65) | HTR1BHTR1DSLC6A4HTR1ADRD1 | |
| SCHEMBL7463335 | 0.79 | APP (0.67) | HTR1BHTR1DHTR1AHTR6HTR1F | |
| SCHEMBL8631546 | 0.78 | HTR1B (0.64) | HTR1BHTR1DSLC6A4HTR1ADRD1 | |
| SCHEMBL8631543 | 0.77 | HTR1B (0.63) | HTR1BHTR1DSLC6A4HTR1ADRD1 | |
| SCHEMBL8631541 | 0.77 | HTR1B (0.63) | HTR1BHTR1DSLC6A4HTR1ADRD1 | |
| SCHEMBL20393325 | 0.76 | HTR1D (0.54) | HTR1BHTR1DHTR1AHTR6HTR1F | |
| SCHEMBL8067512 | 0.75 | HTR1B (0.80) | HTR1BHTR1DSLC6A4HTR1ADRD1 | |
| SCHEMBL8067517 | 0.75 | HTR1B (0.80) | HTR1BHTR1DSLC6A4HTR1ADRD1 | |
| SCHEMBL9035059 | 0.75 | HTR1B (0.74) | HTR1BHTR1DSLC6A4HTR1ADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995020588-A1 | INDOLE DERIVATIVES AS 5-HT1 AGONISTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-08-03 | — | — | WO | claimed |
| US-6103752-A | PHTHALIMIDE DERIVATIVE AS HT3 RECEPTOR ANTAGONIST | GLAXO WELLCOME INC. (US) | 2000-08-15 | — | — | US | disclosed |
| US-5922748-A | TREATMENT OF HEADACHES AND MIGRAINES | GLAXO WELLCOME INC. (US) | 1999-07-13 | — | — | US | disclosed |
| US-5744466-A | ANTISEROTONIN AGENT | THE WELLCOME FOUNDATION LIMITED (GB) | 1998-04-28 | — | — | US | disclosed |
| WO-1995020588-A1 | INDOLE DERIVATIVES AS 5-HT1 AGONISTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-08-03 | — | — | WO | disclosed |