Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 6/20 | 0.67 |
| ▸ | NMT2 | O60551 | 1/20 | 0.55 |
| ▸ | NMT1 | P30419 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 2/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
| ▸ | HTR1D | P28221 | 9/20 | 0.48 |
| ▸ | HTR1B | P28222 | 9/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | HTR1F | P30939 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20393325 | 0.84 | HTR1D (0.54) | APPHTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL12129538 | 0.80 | APP (1.00) | APPNMT2NMT1HTR2CADRB2 | |
| SCHEMBL5357785 | 0.80 | APP (0.64) | APPNMT2NMT1HTR2CADRB2 | |
| SCHEMBL4671538 | 0.80 | HTR1D (0.74) | APPNMT2NMT1HTR2CADRB2 | |
| SCHEMBL8058252 | 0.79 | HTR1B (0.59) | HTR1DHTR1BHTR1AHTR1FHTR6 | |
| SCHEMBL8058248 | 0.79 | HTR1B (0.59) | HTR1DHTR1BHTR1AHTR1FHTR6 | |
| SCHEMBL20393394 | 0.77 | RORC (0.64) | APPHTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL12129567 | 0.77 | APP (0.82) | APPNMT2NMT1HTR2CADRB2 | |
| Phosphoric Acid SCHEMBL7867945 | 0.77 | HTR1D (0.53) | HTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL7478523 | 0.76 | HTR1D (0.60) | APPNMT2NMT1HTR2CADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3428160-A1 | HETEROBICYCLOARYL RORC2 INHIBITORS AND METHODS OF USE THEREOF | Pfizer Inc (US) | 2019-01-16 | — | — | EP | disclosed |
| EP-0708102-B1 | 5-HT1F agonists for the treatment of migraine | LILLY CO ELI (US) | 2002-12-11 | — | — | EP | disclosed |
| US-5721252-A | PIPERIDINYL-1H-INDOLE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1998-02-24 | — | — | US | disclosed |
| US-5521196-A | ANALGESICS USING SEROTONIN ANTAGONIST | ELI LILLY AND COMPANY (US) | 1996-05-28 | — | — | US | disclosed |
| EP-0708102-A1 | 5-HT1F agonists for the treatment of migraine | ELI LILLY AND COMPANY (US) | 1996-04-24 | — | — | EP | disclosed |