SCHEMBL8058476

SCHEMBL8058476

NC1=NC(c2ccc(F)cc2)Cc2cc(F)ccc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
NOS3 P29474 17/20 1.00
NOS2 P35228 10/20 1.00
GSK3B P49841 1/20 0.47
BACE1 P56817 1/20 0.47
KDM1A O60341 1/20 0.37
MAOB P27338 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8098227 0.98 NOS3 (0.97) NOS3NOS2GSK3BBACE1KDM1A
SCHEMBL8060978 0.88 NOS3 (1.00) NOS3NOS2GSK3BBACE1KDM1A
Hydrochloric Acid SCHEMBL8105417 0.86 NOS3 (0.97) NOS3NOS2GSK3BBACE1KDM1A
SCHEMBL8057575 0.84 NOS3 (1.00) NOS3NOS2GSK3BBACE1
Hydrochloric Acid SCHEMBL8090685 0.83 NOS3 (0.97) NOS3NOS2GSK3BBACE1
SCHEMBL8060901 0.75 NOS3 (1.00) NOS3NOS2
Hydrochloric Acid SCHEMBL8099002 0.74 NOS3 (0.97) NOS3NOS2
SCHEMBL8060982 0.73 NOS3 (0.68) NOS3NOS2
SCHEMBL8058500 0.73 NOS3 (1.00) NOS3NOS2GSK3BBACE1KDM1A
SCHEMBL8058383 0.73 NOS3 (1.00) NOS3NOS2GSK3BBACE1KDM1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1027052-A1 NOVEL COMBINATION AstraZeneca UK Limited (GB) 2000-08-16 EP claimed
US-6046191-A PHARMACEUTICAL COMBINATION COMPRISING A COX-2 INHIBITOR OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND AN AMIDINE COMPOUND; FOR TREATMENT OF INFLAMMATORY DISORDERS ASTRA PHARMACEUTICALS LTD. (GB) 2000-04-04 US claimed
WO-1999018960-A1 NOVEL COMBINATION ASTRAZENECA UK LIMITED (GB) 1999-04-22 WO claimed
EP-0892784-A1 AMINOISOQUINOLINES AND AMINOTHIENOPYRIDINE DERIVATIVES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS Astra Pharmaceuticals Limited (GB) 1999-01-27 EP claimed
WO-1997038977-A1 AMINOISOQUINOLINES AND AMINOTHIENOPYRIDINE DERIVATIVES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS ASTRA PHARMACEUTICALS LTD. (GB) 1997-10-23 WO claimed
EP-1027052-A1 NOVEL COMBINATION AstraZeneca UK Limited (GB) 2000-08-16 EP disclosed
US-6046191-A PHARMACEUTICAL COMBINATION COMPRISING A COX-2 INHIBITOR OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND AN AMIDINE COMPOUND; FOR TREATMENT OF INFLAMMATORY DISORDERS ASTRA PHARMACEUTICALS LTD. (GB) 2000-04-04 US disclosed
WO-1999018960-A1 NOVEL COMBINATION ASTRAZENECA UK LIMITED (GB) 1999-04-22 WO disclosed