SCHEMBL8058490

SCHEMBL8058490

[CH2]Cc1ccc2ccsc2c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 2/20 0.46
MRGPRX4 Q96LA9 1/20 0.36
OPRM1 P35372 1/20 0.36
OPRK1 P41145 1/20 0.36
SIGMAR1 Q99720 1/20 0.32
PTPRC P08575 1/20 0.31
PTPN6 P29350 1/20 0.31
PTPN11 Q06124 1/20 0.31
PTPN22 Q9Y2R2 1/20 0.31
DYRK1A Q13627 1/20 0.31
PTGER4 P35408 1/20 0.31
PTGER3 P43115 1/20 0.31
SLC6A2 P23975 1/20 0.31
SLC6A4 P31645 1/20 0.31
SLC6A3 Q01959 1/20 0.31
CTNNB1 P35222 1/20 0.30
WNT3A P56704 1/20 0.30
PSEN1 P49768 1/20 0.30
PSEN2 P49810 1/20 0.30
APH1B Q8WW43 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8051994 0.83 CYP2A6 (0.66) CYP2A6MRGPRX4OPRM1OPRK1SIGMAR1
SCHEMBL2092291 0.81 CYP2A6 (0.41) CYP2A6MRGPRX4OPRM1OPRK1SIGMAR1
SCHEMBL154793 0.79 CYP2A6 (0.47) CYP2A6MRGPRX4OPRM1OPRK1SIGMAR1
SCHEMBL7465357 0.79 CYP2A6 (0.46) CYP2A6MRGPRX4OPRM1OPRK1SIGMAR1
SCHEMBL3150204 0.79 CYP2A6 (0.46) CYP2A6MRGPRX4OPRM1OPRK1PTPRC
SCHEMBL507426 0.79 CYP2A6 (0.71) CYP2A6MRGPRX4OPRM1OPRK1DYRK1A
SCHEMBL3810731 0.76 KDM4E (0.44) CYP2A6MRGPRX4OPRM1OPRK1SIGMAR1
SCHEMBL29833385 0.76 CYP2A6 (0.43) CYP2A6MRGPRX4OPRM1OPRK1SIGMAR1
SCHEMBL12569411 0.76 CYP2A6 (0.52) CYP2A6SLC6A2SLC6A3
SCHEMBL3799097 0.76 CYP2A6 (0.43) CYP2A6MRGPRX4OPRM1OPRK1SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6040449-A USEFUL FOR FORMING FLUORINE CONTAINING 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES, USEFUL AS ANTAGONIST FOR MUSCARINIC M3 RECEPTORS AND LESS SIDE EFFECT BANYU PHARMACEUTICAL CO LTD (JP) 2000-03-21 US disclosed
US-5948792-A POTENT AND SELECTIVE ANTAGONISTS FOR MUSCARINIC M.SUB.3 RECEPTORS WITH LITTLE SIDE EFFECTS. BANYU PHARMACEUTICAL CO., LTD. (JP) 1999-09-07 US disclosed
CN-1226888-A Fluorinated 1,4-disubstituted piperidine derivatives BANYU PHARMA CO LTD (JP) 1999-08-25 CN disclosed
EP-0930298-A1 FLUORINATED 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES BANYU PHARMACEUTICAL CO., LTD. (JP) 1999-07-21 EP disclosed