SCHEMBL8058602

SCHEMBL8058602

COC(=O)/C(C)=C/c1ccc(C(F)(F)F)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 4/20 0.47
PTGS2 P35354 3/20 0.47
NQO2 P16083 1/20 0.47
HDAC3 O15379 1/20 0.46
ADAM17 P78536 1/20 0.46
HDAC1 Q13547 1/20 0.46
HDAC2 Q92769 1/20 0.46
HDAC10 Q969S8 1/20 0.46
HDAC11 Q96DB2 1/20 0.46
HDAC8 Q9BY41 1/20 0.46
HDAC6 Q9UBN7 1/20 0.46
HDAC5 Q9UQL6 1/20 0.46
CYP1A2 P05177 1/20 0.46
CYP1A1 P04798 1/20 0.44
CYP1B1 Q16678 1/20 0.44
MAOB P27338 1/20 0.44
AKR1C3 P42330 1/20 0.43
NR4A1 P22736 1/20 0.42
NR4A2 P43354 1/20 0.42
NR4A3 Q92570 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8058606 1.00 PTGS1 (0.47) PTGS1PTGS2NQO2HDAC3ADAM17
SCHEMBL28915270 0.85 CYP1A2 (0.47) HDAC1CYP1A2ALDH1A1
SCHEMBL30103347 0.85 CYP1A2 (0.47) HDAC1CYP1A2ALDH1A1
SCHEMBL13539102 0.85 HDAC3 (0.47) PTGS1PTGS2NQO2HDAC3ADAM17
SCHEMBL8880883 0.84 ALDH1A1 (0.46) PTGS1PTGS2NQO2HDAC3ADAM17
SCHEMBL8880889 0.84 ALDH1A1 (0.46) PTGS1PTGS2NQO2HDAC3ADAM17
SCHEMBL30587843 0.83 HDAC3 (0.46) PTGS1PTGS2NQO2HDAC3ADAM17
SCHEMBL16969110 0.83 NPSR1 (0.55) PTGS1PTGS2NQO2CYP1A2CYP1A1
SCHEMBL6064986 0.82 HDAC3 (0.45) PTGS1PTGS2NQO2HDAC3ADAM17
SCHEMBL8654689 0.81 HDAC3 (0.45) PTGS1PTGS2NQO2HDAC3ADAM17

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6127392-A A MUSCLE RELAXANT FOR TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION; INOTROPIC AGENT AMERICAN HOME PRODUCTS CORPORATION (US) 2000-10-03 US disclosed
EP-1003712-A1 ANTHRANILIC ACID ANALOGS AMERICAN HOME PRODUCTS CORPORATION (US) 2000-05-31 EP disclosed
US-6046239-A USED IN THE TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION, VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION SUCH AS URINARY INCONTINENCE, ASTHMA, ANGINA, PREMATURE LABOR, CONGESTIVE HEART FAILURE AMERICAN HOME PRODUCTS CORPORATION (US) 2000-04-04 US disclosed
WO-1999007669-A1 ANTHRANILIC ACID ANALOGS AMERICAN HOME PRODUCTS CORPORATION (US) 1999-02-18 WO disclosed