Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 9/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.56 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.56 |
| ▸ | UGT1A4 | P22310 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | FNTA | P49354 | 3/20 | 0.43 |
| ▸ | FNTB | P49356 | 3/20 | 0.43 |
| ▸ | PGGT1B | P53609 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2350295 | 0.91 | CYP19A1 (0.58) | CYP11B1CYP19A1CYP11B2UGT1A4PDE4D | |
| Anastrozole SCHEMBL9717292 | 0.81 | CYP19A1 (0.79) | CYP11B1CYP19A1CYP11B2UGT1A4PDE4D | |
| SCHEMBL8070045 | 0.81 | CYP11B1 (0.61) | CYP11B1CYP19A1CYP11B2FNTAFNTB | |
| SCHEMBL8074623 | 0.80 | CYP19A1 (0.44) | CYP11B1CYP19A1CYP11B2UGT1A4PDE4D | |
| SCHEMBL8070226 | 0.79 | CYP19A1 (0.50) | CYP11B1CYP19A1CYP11B2FNTAFNTB | |
| SCHEMBL13590044 | 0.79 | CYP19A1 (0.68) | CYP11B1CYP19A1CYP11B2UGT1A4PDE4D | |
| SCHEMBL8059020 | 0.77 | CYP19A1 (0.82) | CYP19A1UGT1A4PDE4D | |
| SCHEMBL14200258 | 0.74 | CYP11B1 (0.62) | CYP11B1CYP19A1CYP11B2 | |
| SCHEMBL17407556 | 0.74 | CYP11B1 (0.62) | CYP11B1CYP19A1CYP11B2 | |
| SCHEMBL4929247 | 0.73 | CYP19A1 (0.60) | CYP11B1CYP19A1CYP11B2UGT1A4PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE36617-E | Anastrozole and salts as anticancer agent | ZENECA LIMITED (GB) | 2000-03-14 | — | — | US | disclosed |
| EP-0296749-B1 | (Substituted aralkyl) heterocyclic compounds | ZENECA LTD (GB) | 1994-10-26 | — | — | EP | disclosed |
| US-4935437-A | (Substituted aralkyl) heterocyclic compounds | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-06-19 | — | — | US | disclosed |